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Fig. 6 | BMC Medical Genomics

Fig. 6

From: Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses

Fig. 6

Differential network analysis of CD4 T cell responses to HDM in sensitized atopics with asthma versus HDM-nonsensitized controls. Gene expression patterns were compared along dimensions of differential expression versus differential connectivity; a HDM-sensitized atopics with asthma versus HDM-nonsensitized controls; b HDM-sensitized atopics with asthma versus HDM-sensitized atopics without asthma. To assign statistical significance to the unpermuted data, we permute the case/control status of the data 1000 times. Region counts can then be compared between permuted and unpermuted data. The data points are colored by their module assignment. Genes in the region 3 of the plots have upregulated expression levels and connectivity patterns in the subjects with asthma. ** P < 0.005

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