Skip to main content

Table 1 Characteristics of the study population

From: Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses

  HDM-nonsensitized controls HDM-sensitized without asthma HDM-sensitized with asthma P-value
Number of participants 24 26 22  
Male (%) 50.0 42.3 63.6 0.333
Age at assessment (years) 14.1 (0.2) 14.1 (0.2) 14.1 (0.1) 0.912
Wheeze in past 12 months [A] (%) 0.0 a 0.0 a 100 b N/A
Doctor diagnosis of asthma ever [B] (%) 29.2 a 26.9 a 100.0 b <0.001
Asthma medication use in past 12 months [C] (%) 0.0 a 19.2 a 100.0 b <0.001
Current medicated asthma
[Postive for A,B &C] (%)
0.0 a 0.0 a 100.0 b <0.001
Bronchial hyperresponsiveness (%) 17.4 a 28.0 a,b 59.1 b 0.009
Total IgE (kU/L) 21.2 a (23.3) 192.7 b (266.3) 479 b (629.7) <0.001
Phadiatop IgE (Phadiatop units) 0.0 a (0.9) 21.4 b (30.6) 74.9 c (127.0) <0.001
Number of allergens to which sensitized 0.0 a (1.7) 2.5 b (3.0) 3.0 b (4.0) <0.001
House dust mite IgE (kU/L) 0.0 a (0.0) 27.1 b (33.0) 84.1 b (160.0) <0.001
House dust mite sensitizeda (%) 0.0 a 100.0 b 100.0 b <0.001
Rye grass sensitized (%) 20.8 a 53.8 b 63.6 b 0.009
Rye grass IgE (kU/L) 0.0 (0.2) 0.4 (4.6) 0.8 (6.0) 0.037*
Cat sensitized (%) 4.2 a 34.6 b 40.9 b 0.009
Cat IgE (kU/L) 0.0 a (0.0) 0.0 b (0.7) 0.3 b (2.9) <0.001
Couch grass sensitized (%) 20.8 38.5 54.5 0.061
Couch grassIgE (kU/L) 0.0 (0.1) 0.1 (1.2) 0.5 (1.9) 0.056
Mould sensitized (%) 16.7 19.2 18.2 0.972
Mould mix IgE (kU/L) 0.0 (0.0) 0.0 (0.1) 0.0 (0.20) 0.293
Peanut sensitized (%) 0.0 a 11.5 a,b 31.8 b 0.007
Peanut IgE (kU/L) 0.0 a (0.0) 0.0 a,b (0.2) 0.1 b (0.5) 0.001
Food mix sensitized (%) 0.0 11.5 18.2 0.107
Food mix IgE (kU/L) 0.0 a (0.0) 0.1 b (0.2) 0.2 b (0.2) <0.001
Positive family history of atopy (%) 61.9 a 63.6 a 95.5 b 0.018
FEV/FVC1 (% ratio) 91.8 (8.6) 92.1 (10.9) 91.9 (17.8) 0.813
Current rhinoconjunctivitis (%) 16.7 a 0.0 a 68.2 b <0.001
Maternal smoking in pregnancy (%) 22.2 31.6 25.0 0.801
Current smokers (%) 0.0 16.0 9.1 0.131
BMI 18.8 (4.3) 20.6 (4.9) 21.0 (4.2) 0.106
Height (cm) 166.8 (9.2) 166.0 (11.1) 161.6 (14.1) 0.246
Weight (kg) 50.5 (17.8) 57.1 (19.8) 54.3 (15.2) 0.278
  1. Median (interquartile range) is displayed for all continuous measures. P value is derived from analyses comparing the three groups: prevalence values were compared by Chi square analysis; continuous measures were compared by Kruskal Wallis analysis. Where significant differences were observed between the three group groups (P < 0.05 in table) subsequent pairwise comparisons were performed; identical letters denote groups that do not differ significantly at the 0.05 level after adjusting for multiple comparisons (a vs a = not different; a vs b = significantly different). aSensitization was defined as specific IgE ≥0.35 kU/L). *Kruskal Wallis analysis found that the three groups were not the same but subsequent pairwise comparisons did not show significant differences (P < 0.05) between groups after P was adjusted for multiple testing