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Table 1 Characteristics of the study population

From: Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses

 

HDM-nonsensitized controls

HDM-sensitized without asthma

HDM-sensitized with asthma

P-value

Number of participants

24

26

22

 

Male (%)

50.0

42.3

63.6

0.333

Age at assessment (years)

14.1 (0.2)

14.1 (0.2)

14.1 (0.1)

0.912

Wheeze in past 12 months [A] (%)

0.0 a

0.0 a

100 b

N/A

Doctor diagnosis of asthma ever [B] (%)

29.2 a

26.9 a

100.0 b

<0.001

Asthma medication use in past 12 months [C] (%)

0.0 a

19.2 a

100.0 b

<0.001

Current medicated asthma

[Postive for A,B &C] (%)

0.0 a

0.0 a

100.0 b

<0.001

Bronchial hyperresponsiveness (%)

17.4 a

28.0 a,b

59.1 b

0.009

Total IgE (kU/L)

21.2 a (23.3)

192.7 b (266.3)

479 b (629.7)

<0.001

Phadiatop IgE (Phadiatop units)

0.0 a (0.9)

21.4 b (30.6)

74.9 c (127.0)

<0.001

Number of allergens to which sensitized

0.0 a (1.7)

2.5 b (3.0)

3.0 b (4.0)

<0.001

House dust mite IgE (kU/L)

0.0 a (0.0)

27.1 b (33.0)

84.1 b (160.0)

<0.001

House dust mite sensitizeda (%)

0.0 a

100.0 b

100.0 b

<0.001

Rye grass sensitized (%)

20.8 a

53.8 b

63.6 b

0.009

Rye grass IgE (kU/L)

0.0 (0.2)

0.4 (4.6)

0.8 (6.0)

0.037*

Cat sensitized (%)

4.2 a

34.6 b

40.9 b

0.009

Cat IgE (kU/L)

0.0 a (0.0)

0.0 b (0.7)

0.3 b (2.9)

<0.001

Couch grass sensitized (%)

20.8

38.5

54.5

0.061

Couch grassIgE (kU/L)

0.0 (0.1)

0.1 (1.2)

0.5 (1.9)

0.056

Mould sensitized (%)

16.7

19.2

18.2

0.972

Mould mix IgE (kU/L)

0.0 (0.0)

0.0 (0.1)

0.0 (0.20)

0.293

Peanut sensitized (%)

0.0 a

11.5 a,b

31.8 b

0.007

Peanut IgE (kU/L)

0.0 a (0.0)

0.0 a,b (0.2)

0.1 b (0.5)

0.001

Food mix sensitized (%)

0.0

11.5

18.2

0.107

Food mix IgE (kU/L)

0.0 a (0.0)

0.1 b (0.2)

0.2 b (0.2)

<0.001

Positive family history of atopy (%)

61.9 a

63.6 a

95.5 b

0.018

FEV/FVC1 (% ratio)

91.8 (8.6)

92.1 (10.9)

91.9 (17.8)

0.813

Current rhinoconjunctivitis (%)

16.7 a

0.0 a

68.2 b

<0.001

Maternal smoking in pregnancy (%)

22.2

31.6

25.0

0.801

Current smokers (%)

0.0

16.0

9.1

0.131

BMI

18.8 (4.3)

20.6 (4.9)

21.0 (4.2)

0.106

Height (cm)

166.8 (9.2)

166.0 (11.1)

161.6 (14.1)

0.246

Weight (kg)

50.5 (17.8)

57.1 (19.8)

54.3 (15.2)

0.278

  1. Median (interquartile range) is displayed for all continuous measures. P value is derived from analyses comparing the three groups: prevalence values were compared by Chi square analysis; continuous measures were compared by Kruskal Wallis analysis. Where significant differences were observed between the three group groups (P < 0.05 in table) subsequent pairwise comparisons were performed; identical letters denote groups that do not differ significantly at the 0.05 level after adjusting for multiple comparisons (a vs a = not different; a vs b = significantly different). aSensitization was defined as specific IgE ≥0.35 kU/L). *Kruskal Wallis analysis found that the three groups were not the same but subsequent pairwise comparisons did not show significant differences (P < 0.05) between groups after P was adjusted for multiple testing
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BMC Medical Genomics

ISSN: 1755-8794

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