Table 8 Overall enrichment and early recognition metrics of the four prioritization strategies considered
From: Efficient and biologically relevant consensus strategy for Parkinson’s disease gene prioritization
Limma | ML | ML-Limma | Consensus | |
|---|---|---|---|---|
Classic Enrichment Metrics | ||||
AUAC | 0.498 | 0.502 | 0.495 | 0.540 |
ROC | 0.498 | 0.502 | 0.495 | 0.541 |
EF 1% | 2.855 | 2.521 | 2.847 | 3.164 |
EF 5% | 1.449 | 1.387 | 1.007 | 1.512 |
EF 10% | 1.038 | 1.385 | 0.913 | 1.510 |
EF 20% | 0.975 | 1.054 | 1.054 | 1.321 |
Early Recognition Metrics | ||||
RIE 1% | 2.452 | 2.213 | 2.403 | 2.577 |
RIE 5% | 1.286 | 1.438 | 1.157 | 1.583 |
RIE 10% | 1.089 | 1.225 | 1.044 | 1.400 |
RIE 20% | 1.021 | 1.085 | 1.008 | 1.230 |
BEDROC 1% | 0.094 | 0.086 | 0.094 | 0.099 |
BEDROC 5% | 0.091 | 0.102 | 0.083 | 0.113 |
BEDROC 10% | 0.131 | 0.147 | 0.125 | 0.168 |
BEDROC 20% | 0.216 | 0.230 | 0.214 | 0.262 |