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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma

Fig. 1

Association results of discovery and validation cohort. a Manhattan plot representing chi-square p-values for 494 genotyped SNPs in the validation phase (319 POAG cases and 297 controls). X-axis represents different chromosomes and Y-axis represents –log10 transformed p-values. The MPP7 SNP (rs10763643) having the lowest association in the validation phase is indicated. b Regional association plot for rs10763643 of MPP7 gene with 100 Kb upstream and downstream regions. The data of genotyped SNPs are denoted as circles while the imputed data is denoted as squares. The arrows represent association of rs10763643 in discovery, validation and the meta analysis. The left Y-axis represents –log10 p-values and the right Y-axis represents the recombination rate. X-axis represents position of SNPs on chromosome 10 (human genome build 36)

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