Skip to main content

Table 1 Details of MPP7 SNPs associated with POAG in Indian population

From: Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma

SNP ID Minor allele Discovery cohort (347 cases/354 controls) Validation cohort (319 cases/297 controls) Meta-analysis (666 cases/651 controls)
MAF (Cases/Controls) plogistic OR (95 % CI) MAF (Cases/Controls) P OR (95 % CI) Pmeta
rs7916852 C 0.54/0.43 9.19x10−4 1.54 (1.25-1.9) 0.61/0.5 1.71x10−4 1.54 (1.23-1.93) 5.7x10−7
rs10763644 G 0.54/0.44 1.24x10−3 1.53 (1.23-1.89) 0.61/0.5 1.33x10−3 1.55 (1.24-1.95) 6.18x10−7
rs10763643 A 0.48/0.4 0.018 1.4 (1.13-1.72) 0.58/0.44 3.35x10−6 1.7 (1.36-2.14) 7.46x10−7
rs4749305 A 0.48/0.4 0.020 1.39 (1.12-1.71) 0.55/0.44 8.42x10−5 1.57 (1.25-1.96) 9.92x10−6
rs11006851 G 0.48/0.4 0.023 1.39 (1.13-1.72) 0.55/0.44 1.26x10−4 1.55 (1.24-1.94) 1.57x10−5
rs10763642 A 0.4/0.49 1.9x10−3 0.69 (0.56-0.85) 0.34/0.42 3.51x10−3 0.71 (0.56-0.89) 2.03x10−5
rs10047289 A 0.4/0.49 3.9x10−3 0.71 (0.57-0.87) 0.34/0.43 2.44x10−3 0.7 (0.56-0.88) 2.92x10−5
rs7474568 A 0.46/0.36 1.82x10−3 1.52 (1.23-1.88) 0.5/0.43 5.42x10−3 1.38 (1.1-1.72) 3.03x10−5
rs4749301 A 0.46/0.36 1.8x10−3 1.52 (1.23-1.88) 0.5/0.42 5.42x10−3 1.38 (1.1-1.72) 3.03x10−5
rs3802520 A 0.36/0.45 6.7x10−3 0.7 (0.56-0.87) 0.33/0.4 9x10−3 0.73 (0.58-0.93) 1.68x10−4
rs7086023 A 0.4/0.33 0.040 1.36 (1.09-1.69) 0.45/0.36 1.78x10−3 1.44 (1.15-1.81) 2.58x10−4
rs12253376 A 0.32/0.41 0.017 0.7 (0.56-0.87) 0.31/0.37 0.025 0.76 (0.6-0.97) 1x10−3
rs3885634 G 0.33/0.41 0.020 0.71 (0.57-0.89) 0.31/0.37 0.021 0.76 (0.6-0.96) 1.11x10−3
rs11006830 G 0.33/0.41 0.022 0.72 (0.58-0.89) 0.31/0.37 0.035 0.78 (0.61-0.98) 1.88x10−3
  1. Note: Plogistic refers to the p-value calculated by logistic regression analysis and P of validation phase refers to chi-square p-value. Pmeta refers to the meta-analysis of Plogistic of discovery phase (see Additional file 2) and P of the validation phase