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Table 1 Details of MPP7 SNPs associated with POAG in Indian population

From: Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma

SNP ID

Minor allele

Discovery cohort (347 cases/354 controls)

Validation cohort (319 cases/297 controls)

Meta-analysis (666 cases/651 controls)

MAF (Cases/Controls)

plogistic

OR (95 % CI)

MAF (Cases/Controls)

P

OR (95 % CI)

Pmeta

rs7916852

C

0.54/0.43

9.19x10−4

1.54 (1.25-1.9)

0.61/0.5

1.71x10−4

1.54 (1.23-1.93)

5.7x10−7

rs10763644

G

0.54/0.44

1.24x10−3

1.53 (1.23-1.89)

0.61/0.5

1.33x10−3

1.55 (1.24-1.95)

6.18x10−7

rs10763643

A

0.48/0.4

0.018

1.4 (1.13-1.72)

0.58/0.44

3.35x10−6

1.7 (1.36-2.14)

7.46x10−7

rs4749305

A

0.48/0.4

0.020

1.39 (1.12-1.71)

0.55/0.44

8.42x10−5

1.57 (1.25-1.96)

9.92x10−6

rs11006851

G

0.48/0.4

0.023

1.39 (1.13-1.72)

0.55/0.44

1.26x10−4

1.55 (1.24-1.94)

1.57x10−5

rs10763642

A

0.4/0.49

1.9x10−3

0.69 (0.56-0.85)

0.34/0.42

3.51x10−3

0.71 (0.56-0.89)

2.03x10−5

rs10047289

A

0.4/0.49

3.9x10−3

0.71 (0.57-0.87)

0.34/0.43

2.44x10−3

0.7 (0.56-0.88)

2.92x10−5

rs7474568

A

0.46/0.36

1.82x10−3

1.52 (1.23-1.88)

0.5/0.43

5.42x10−3

1.38 (1.1-1.72)

3.03x10−5

rs4749301

A

0.46/0.36

1.8x10−3

1.52 (1.23-1.88)

0.5/0.42

5.42x10−3

1.38 (1.1-1.72)

3.03x10−5

rs3802520

A

0.36/0.45

6.7x10−3

0.7 (0.56-0.87)

0.33/0.4

9x10−3

0.73 (0.58-0.93)

1.68x10−4

rs7086023

A

0.4/0.33

0.040

1.36 (1.09-1.69)

0.45/0.36

1.78x10−3

1.44 (1.15-1.81)

2.58x10−4

rs12253376

A

0.32/0.41

0.017

0.7 (0.56-0.87)

0.31/0.37

0.025

0.76 (0.6-0.97)

1x10−3

rs3885634

G

0.33/0.41

0.020

0.71 (0.57-0.89)

0.31/0.37

0.021

0.76 (0.6-0.96)

1.11x10−3

rs11006830

G

0.33/0.41

0.022

0.72 (0.58-0.89)

0.31/0.37

0.035

0.78 (0.61-0.98)

1.88x10−3

  1. Note: Plogistic refers to the p-value calculated by logistic regression analysis and P of validation phase refers to chi-square p-value. Pmeta refers to the meta-analysis of Plogistic of discovery phase (see Additional file 2) and P of the validation phase