Fig. 4
Kaplan-Meier curves of recurrence-free survival as delineated by Milan criteria and clustering on all 89 patients. The patients within Milan are not stratified by their microRNA expression profile because microRNA expression is not significantly associated with survival for patients within Milan (Figure S5). Recurrence-free survival time is strongly differentiated by subgroups defined by the Milan criteria and microRNA expression profiles (p-value = 1.6x10−13). Of note is that patients outside Milan whose samples all fall in cluster 2 (dashed black) have recurrence survival times that are nearly as good as patients within Milan (p-value = 0.44). Moreover, both of these subgroups have significantly different recurrence-free survival times than the other two subgroups: Outside Milan & Cluster 1 (7 patients) vs. Outside Milan & Cluster 2 (28 patients): p-value = 1.05x10−7; Outside Milan & Cluster 1 vs. Within Milan (37 patients): p-value = 1.03x10−12; Outside Milan & Mixed (17 patients) vs. Outside Milan & Cluster 2: p-value = 2.28x10−3; Outside Milan & Mixed vs. Within Milan: p-value = 1.89x10−5