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Table 1 Characteristics of subjects included into the study

From: Longitudinal genome-wide methylation study of Roux-en-Y gastric bypass patients reveals novel CpG sites associated with essential hypertension

 

Discovery groupa

Verification cohort

Parameter

 

EH

NT

N

11

275

264

Men: Women (n (%))

7:4

140 (50.9):135 (49.1)

127 (48.1):137 (51.9)

Caucasian: Hispanic (n (%))

11:0

132 (48.0):143 (52.0)

97 (36.7):167 (53.3)

Age (years, n (%))

   

 0–19

1 (0.4)

 20–29

1 (9.1)

10 (3.8)

 30–39

1 (9.1)

7 (2.5)

11 (4.2)

 40–49

4 (36.4)

26 (9.5)

38 (14.4)

 50–59

3 (27.3)

70 (25.5)

48 (18.2)

 60–69

2 (18.2)

73 (26.5)

66 (25.0)

 70–79

59 (21.5)

51 (19.3)

 80–89

34 (12.4)

33 (12.5)

 90–99

5 (1.8)

6 (2.3)

 100+

1 (0.4)

 Mean (SD)

46.9 (11.9)

64.9 (13.2)

62.3 (16.4)

Body mass index (BMI)

   

 BaselineA

47.9 (6.9)

29.6 (6.1)

26.9 (4.8)

 Post surgeryB

36.0 (6.7)

p: A vs. B

6.21E–09

Diastolic blood pressure

   

 BaselineA

91.6 (12.8)

N/A

N/A

 Post surgeryB

82.7 (7.2)

p: A vs. B

1.48E–02

Systolic blood pressure

   

 BaselineA

144.5 (16.0)

N/A

N/A

 Post surgeryB

125.9 (14.7)

p: A vs. B

6.78E–03

  1. Abbreviations: EH essential hypertension, NT normotensive, RYGB Roux-en-Y gastric bypass, N/A not applicable
  2. aThis group comprises patients who underwent RYGB surgery. Values at baseline and post-surgery are shown as mean values (SD). P-values were calculated by means of pairwise t-tests, contrasting values at baseline and six months after RYGB-surgery (p: A vs. B). A one-tailed p-value <0.05 was considered significant