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Table 1 Characteristics of subjects included into the study

From: Longitudinal genome-wide methylation study of Roux-en-Y gastric bypass patients reveals novel CpG sites associated with essential hypertension

  Discovery groupa Verification cohort
Parameter   EH NT
N 11 275 264
Men: Women (n (%)) 7:4 140 (50.9):135 (49.1) 127 (48.1):137 (51.9)
Caucasian: Hispanic (n (%)) 11:0 132 (48.0):143 (52.0) 97 (36.7):167 (53.3)
Age (years, n (%))    
 0–19 1 (0.4)
 20–29 1 (9.1) 10 (3.8)
 30–39 1 (9.1) 7 (2.5) 11 (4.2)
 40–49 4 (36.4) 26 (9.5) 38 (14.4)
 50–59 3 (27.3) 70 (25.5) 48 (18.2)
 60–69 2 (18.2) 73 (26.5) 66 (25.0)
 70–79 59 (21.5) 51 (19.3)
 80–89 34 (12.4) 33 (12.5)
 90–99 5 (1.8) 6 (2.3)
 100+ 1 (0.4)
 Mean (SD) 46.9 (11.9) 64.9 (13.2) 62.3 (16.4)
Body mass index (BMI)    
 BaselineA 47.9 (6.9) 29.6 (6.1) 26.9 (4.8)
 Post surgeryB 36.0 (6.7)
p: A vs. B 6.21E–09
Diastolic blood pressure    
 BaselineA 91.6 (12.8) N/A N/A
 Post surgeryB 82.7 (7.2)
p: A vs. B 1.48E–02
Systolic blood pressure    
 BaselineA 144.5 (16.0) N/A N/A
 Post surgeryB 125.9 (14.7)
p: A vs. B 6.78E–03
  1. Abbreviations: EH essential hypertension, NT normotensive, RYGB Roux-en-Y gastric bypass, N/A not applicable
  2. aThis group comprises patients who underwent RYGB surgery. Values at baseline and post-surgery are shown as mean values (SD). P-values were calculated by means of pairwise t-tests, contrasting values at baseline and six months after RYGB-surgery (p: A vs. B). A one-tailed p-value <0.05 was considered significant