Discovery groupa (n=11) | Verification cohortb (n=539) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
% DNA Methylation (SD) | Spearman’s rank correlation coefficients (SBP) | Binary logistic regressions (EH) | ||||||||||
Gene | Illumina ID | Distance to TSS | BaselineA | After surgeryB | p A vs. B | Coef. | p | p (Bonf.) | % DNA Methylation (SD) | Exp (B) | p | p (Bonf.) |
MCCC1 | cg00161968 | 27 | 5.36 (1.1) | 5.9 (1.7) | ns | 0.93 | <10E–16 | <10E–16 | 7.5 (4.3) | – | ns | ns |
SKOR2 | cg00875989 | 1500 | 33.2 (1.7) | 33.6 (3.6) | ns | (0.92) | <10E–16 | <10E–16 | 37.5 (4.2) | 0.92 | 1.16E–03 | 2.79E–02 |
VGLL3 | cg06251539 | 375 | 9.3 (2.4) | 8.7 (1.88) | ns | 0.92 | <10E–16 | <10E–16 | 14.5 (3.1) | – | ns | ns |
WSB1 | cg08706258 | 125 | 4.3 (1.1) | 4.2 (0.7) | ns | 0.93 | <10E–16 | <10E–16 | 4.8 (0.8) | – | ns | ns |
EHMT2 | cg09134341 | (1332) | 91.0 (2.8) | 91.8 (1.2) | ns | (0.92) | <10E–16 | <10E–16 | 89.3 (1.9) | 0.84 | 9.58E–04 | 2.30E–02 |
TCF12 | cg10146710 | 1132 | 2.4 (0.5) | 2.4 (0.4) | ns | 0.92 | <10E–16 | <10E–16 | 2.3 (1.0) | – | ns | ns |
MAP2K4 | cg10596925 | (242) | 12.1 (3.4) | 13.0 (2.0) | ns | 0.95 | <10E–16 | <10E–16 | 10.7 (2.9) | 0.94 | 4.98E–02 | ns |
FAM54A | cg10640093 | (196) | 3.8 (1.0) | 4.1 (0.7) | ns | 0.94 | <10E–16 | <10E–16 | 3.0 (0.7) | – | ns | ns |
SORBS1 | cg12360759 | 598 | 7.4 (1.7) | 7.4 (1.0) | ns | 0.92 | <10E–16 | <10E–16 | 9.1 (1.3 | 0.82 | 6.33E–03 | ns |
DDX55 | cg15612682 | 232 | 6.0 (1.5) | 6.1 (0.8) | ns | 0.93 | <10E–16 | <10E–16 | 5.6 (1.0) | – | ns | ns |
ATXN1L | cg16076930 | 380 | 19.0 (2.8) | 20.5 (5.1) | ns | 0.94 | <10E–16 | <10E–16 | 21.1 (2.8) | – | ns | ns |
EFEMP1 | cg16118212 | 227 | 12.7 (4.4) | 10.7 (2.9) | ns | 0.92 | <10E–16 | <10E–16 | 17.3 (6.2) | – | ns | ns |
CRKL | cg16500810 | (197) | 1.5 (0.3) | 1.6 (0.9) | ns | 0.92 | <10E–16 | <10E–16 | 0.6 (0.6) | – | ns | ns |
STEAP3 | cg18643762 | (211) | 2.9 (1.0) | 3.4 (1.0) | ns | (0.93) | <10E–16 | <10E–16 | 1.7 (1.3) | – | ns | ns |
CPEB4 | cg20841073 | 648 | 10.7 (2.2) | 10.3 (2.7) | ns | 0.93 | <10E–16 | <10E–16 | 5.2 (2.0) | 0.85 | 2.37E–03 | ns |
RHOBTB2 | cg21344124 | 302 | 3.2 (0.7) | 2.8 (1.1) | ns | 0.92 | <10E–16 | <10E–16 | 2.2 (0.7) | 1.34 | 1.96E–02 | ns |
ATXN1 | cg21996137 | (185) | 2.0 (0.7) | 1.8 (0.6) | ns | 0.92 | <10E–16 | <10E–16 | 1.6 (0.7) | 1.42 | 1.60E–02 | ns |
TSSK1B | cg22011370 | 525 | 89.9 (2.6) | 89.9 (2.9) | ns | (0.95) | <10E–16 | <10E–16 | 90.6 (3.3) | – | ns | ns |
SPPL2A | cg22295383 | (104) | 5.2 (1.3) | 4.9 (1.1) | ns | 0.94 | <10E–16 | <10E–16 | 4.2 (1.3) | – | ns | ns |
BHLHA9 | cg23945265 | 1003 | 45.4 (4.2) | 46.9 (3.2) | ns | (0.92) | <10E–16 | <10E–16 | 45.7 (5.2) | 0.96 | 2.58E–02 | ns |
CHCHD5 | cg25521086 | (58) | 4.0 (0.8) | 3.8 (0.7) | ns | 0.95 | <10E–16 | <10E–16 | 3.1 (1.2) | – | ns | ns |
NRTN | cg25544164 | 342 | 99.0 (0.3) | 9.1 (0.2) | ns | 0.94 | <10E–16 | <10E–16 | 99.1 (0.5) | – | ns | ns |