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Table 2 CpG sites significantly correlated with SBP and EH

From: Longitudinal genome-wide methylation study of Roux-en-Y gastric bypass patients reveals novel CpG sites associated with essential hypertension

   

Discovery groupa (n=11)

Verification cohortb (n=539)

   

% DNA Methylation (SD)

Spearman’s rank correlation coefficients (SBP)

 

Binary logistic regressions (EH)

Gene

Illumina ID

Distance to TSS

BaselineA

After surgeryB

p A vs. B

Coef.

p

p (Bonf.)

% DNA Methylation (SD)

Exp (B)

p

p (Bonf.)

MCCC1

cg00161968

27

5.36 (1.1)

5.9 (1.7)

ns

0.93

<10E–16

<10E–16

7.5 (4.3)

ns

ns

SKOR2

cg00875989

1500

33.2 (1.7)

33.6 (3.6)

ns

(0.92)

<10E–16

<10E–16

37.5 (4.2)

0.92

1.16E–03

2.79E–02

VGLL3

cg06251539

375

9.3 (2.4)

8.7 (1.88)

ns

0.92

<10E–16

<10E–16

14.5 (3.1)

ns

ns

WSB1

cg08706258

125

4.3 (1.1)

4.2 (0.7)

ns

0.93

<10E–16

<10E–16

4.8 (0.8)

ns

ns

EHMT2

cg09134341

(1332)

91.0 (2.8)

91.8 (1.2)

ns

(0.92)

<10E–16

<10E–16

89.3 (1.9)

0.84

9.58E–04

2.30E–02

TCF12

cg10146710

1132

2.4 (0.5)

2.4 (0.4)

ns

0.92

<10E–16

<10E–16

2.3 (1.0)

ns

ns

MAP2K4

cg10596925

(242)

12.1 (3.4)

13.0 (2.0)

ns

0.95

<10E–16

<10E–16

10.7 (2.9)

0.94

4.98E–02

ns

FAM54A

cg10640093

(196)

3.8 (1.0)

4.1 (0.7)

ns

0.94

<10E–16

<10E–16

3.0 (0.7)

ns

ns

SORBS1

cg12360759

598

7.4 (1.7)

7.4 (1.0)

ns

0.92

<10E–16

<10E–16

9.1 (1.3

0.82

6.33E–03

ns

DDX55

cg15612682

232

6.0 (1.5)

6.1 (0.8)

ns

0.93

<10E–16

<10E–16

5.6 (1.0)

ns

ns

ATXN1L

cg16076930

380

19.0 (2.8)

20.5 (5.1)

ns

0.94

<10E–16

<10E–16

21.1 (2.8)

ns

ns

EFEMP1

cg16118212

227

12.7 (4.4)

10.7 (2.9)

ns

0.92

<10E–16

<10E–16

17.3 (6.2)

ns

ns

CRKL

cg16500810

(197)

1.5 (0.3)

1.6 (0.9)

ns

0.92

<10E–16

<10E–16

0.6 (0.6)

ns

ns

STEAP3

cg18643762

(211)

2.9 (1.0)

3.4 (1.0)

ns

(0.93)

<10E–16

<10E–16

1.7 (1.3)

ns

ns

CPEB4

cg20841073

648

10.7 (2.2)

10.3 (2.7)

ns

0.93

<10E–16

<10E–16

5.2 (2.0)

0.85

2.37E–03

ns

RHOBTB2

cg21344124

302

3.2 (0.7)

2.8 (1.1)

ns

0.92

<10E–16

<10E–16

2.2 (0.7)

1.34

1.96E–02

ns

ATXN1

cg21996137

(185)

2.0 (0.7)

1.8 (0.6)

ns

0.92

<10E–16

<10E–16

1.6 (0.7)

1.42

1.60E–02

ns

TSSK1B

cg22011370

525

89.9 (2.6)

89.9 (2.9)

ns

(0.95)

<10E–16

<10E–16

90.6 (3.3)

ns

ns

SPPL2A

cg22295383

(104)

5.2 (1.3)

4.9 (1.1)

ns

0.94

<10E–16

<10E–16

4.2 (1.3)

ns

ns

BHLHA9

cg23945265

1003

45.4 (4.2)

46.9 (3.2)

ns

(0.92)

<10E–16

<10E–16

45.7 (5.2)

0.96

2.58E–02

ns

CHCHD5

cg25521086

(58)

4.0 (0.8)

3.8 (0.7)

ns

0.95

<10E–16

<10E–16

3.1 (1.2)

ns

ns

NRTN

cg25544164

342

99.0 (0.3)

9.1 (0.2)

ns

0.94

<10E–16

<10E–16

99.1 (0.5)

ns

ns

  1. Abbreviations: EH essential hypertension, Exp(B) log odds ratio, ns not significant, RYGB Roux-en-Y gastric bypass, SBP systolic blood pressure, SD standard deviation, TSS transcription start site
  2. aThis group comprises patients who underwent RYGB surgery. bResults were derived from binary logistic regressions of EH (yes/no) to % CpG site methylation, age, BMI, ethnicity and sex. Log odds ratios and p-values refer to the CpG site in focus. P-values for DNA methylation levels were calculated by paired t-tests, contrasting methylation levels at baseline and six months after RYGB-surgery (p: A vs. B). GWAS results for SBP were calculated by genome-wide analyses of Spearman's rank correlation coefficients using algorithm AS 89 and an Edgeworth series approximation. Unless specified as SD, parenthesis “()” implies negative numbers