Longitudinal genome-wide methylation study of Roux-en-Y gastric bypass patients reveals novel CpG sites associated with essential hypertension

Table 3 CpG site associations to age, BMI, DBP and glucose

Discovery cohort^a (n = 11)
		Spearman’s rank correlation coefficients
Gene	Illumina ID	p (Age)	p (BMI)	p (DBP)	p (Glucose)
MCCC1	cg00161968	ns	ns	ns	ns
SKOR2	cg00875989	ns	ns	ns	ns
VGLL3	cg06251539	ns	ns	ns	ns
WSB1	cg08706258	ns	ns	ns	ns
EHMT2	cg09134341	ns	ns	ns	ns
TCF12	cg10146710	ns	ns	ns	2.81E–02
MAP2K4	cg10596925	ns	ns	ns	ns
FAM54A	cg10640093	ns	ns	ns	ns
SORBS1	cg12360759	ns	ns	ns	ns
DDX55	cg15612682	ns	ns	ns	ns
ATXN1L	cg16076930	ns	ns	ns	ns
EFEMP1	cg16118212	ns	ns	ns	ns
CRKL	cg16500810	ns	ns	ns	2.08E–02
STEAP3	cg18643762	ns	ns	ns	ns
CPEB4	cg20841073	ns	ns	ns	ns
RHOBTB2	cg21344124	ns	ns	ns	ns
ATXN1	cg21996137	ns	ns	ns	ns
TSSK1B	cg22011370	ns	ns	ns	4.04E–02
SPPL2A	cg22295383	ns	ns	ns	ns
BHLHA9	cg23945265	ns	ns	ns	4.78E–02
CHCHD5	cg25521086	ns	ns	ns	ns
NRTN	cg25544164	ns	ns	ns	ns

Abbreviations: DB diastolic blood pressure, ns, not significant, RYGB, Roux-en-Y gastric bypass, SBP systolic blood pressure
^aCohort comprises patients who underwent RYGB surgery. P-values were derived by analyses of Spearman’s rank correlation coefficients using algorithm AS 89 and an Edgeworth series approximation. For the variables DBP, BMI and fasting plasma glucose, percent change in methylation states were correlated with percent change in these variables, measured before and six months after RYGB surgery. For the variable age, percent change in methylation states measured before and six months after RYGB surgery was correlated with age.

ISSN: 1755-8794