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Table 2 Associations between biogenesis genes and cancer risk for those SNPs that had a raw p-value of <0.05

From: Impact of polymorphisms in microRNA biogenesis genes on colon cancer risk and microRNA expression levels: a population-based, case-control study

  Controls Cases  
N % N % OR (95 % CI) P-valuea,b P Holmb VEP Prediction
AGO2 (rs6985156)
 GG 912 77.7 858 77.0 1.00   0.030 0.395  
 GA 250 21.3 230 20.6 0.98 (0.80, 1.20)    
 AA 11 0.9 27 2.4 2.59 (1.27, 5.26)    
 GG/GA vs. AA 11 0.9 27 2.4 2.6 (1.28, 5.28)    Modifier
AGO2 (rs7843258)
 CC 810 69.1 779 69.9 1.00   0.031 0.395  
 CT 342 29.2 298 26.7 0.90 (0.75, 1.08)    
 TT 21 1.8 38 3.4 1.87 (1.09, 3.23)    
 CC/CT vs.TT 21 1.8 38 3.4 1.93 (1.12, 3.32)    Modifier
AGO2 (rs2176397)
 CC 567 48.3 568 50.9 1.00   0.019 0.273  
 CT 517 44.1 435 39.0 0.85 (0.71, 1.01)    
 TT 89 7.6 112 10.0 1.26 (0.93, 1.71)    
 CC/CT vs. TT 89 7.6 112 10 1.36 (1.02, 1.83)    Modifier
AGO2 (rs4961278)
 AA 605 51.6 578 51.8 1.00   0.032 0.395  
 AG 501 42.7 444 39.8 0.92 (0.78, 1.09)    
 GG 67 5.7 93 8.3 1.45 (1.04, 2.03)    
 AA/AG vs. GG 67 5.7 93 8.3 1.51 (1.09, 2.09)    Modifier
BMP2 (rs3178250)
 TT 747 63.7 663 59.5 1.00   0.014 0.040  
 TC 371 31.6 415 37.2 1.24 (1.04, 1.48)    
 CC 55 4.7 37 3.3 0.75 (0.49, 1.16)    
 TT vs.TC/CC 426 36.3 452 40.5 1.18 (0.99, 1.40)    Modifier
DGCR8 (rs11089328)
 AA 400 34.1 432 38.7 1.00   0.009 0.066  
 AG 586 50.0 491 44.0 0.76 (0.63, 0.91)    
 GG 187 15.9 192 17.2 0.94 (0.74, 1.20)    
 AA vs. AG/GG 773 65.9 683 61.3 0.80 (0.68, 0.96)    Modifier
DROSHA (rs2287584)
 TT 743 63.3 742 66.5 1.00   0.032 0.384  
 TC 394 33.6 325 29.1 0.82 (0.69, 0.99)    
 CC 36 3.1 48 4.3 1.33 (0.85, 2.08)    
 TT/TC vs. CC 36 3.1 48 4.3 1.42 (0.91, 2.20)    Low
DROSHA (rs17410035)
 GG 552 47.1 468 42.0 1.00   0.014 0.181  
 GT 473 40.3 518 46.5 1.29 (1.08, 1.53)    
 TT 148 12.6 129 11.6 1.01 (0.77, 1.32)    
 GG vs. GT/TT 621 52.9 647 58.0 1.22 (1.03, 1.44)    Modifierc
GEMIN4 (rs2740348)
 CC 782 66.7 798 71.6 1.00   0.048 0.241  
 CG 352 30.0 286 25.7 0.80 (0.67, 0.96)    
 GG 39 3.3 31 2.8 0.78 (0.48, 1.27)    
 CC vs. CG/GG 391 33.3 317 28.4 0.80 (0.67, 0.96)    Moderate
MAPKAPK2 (rs4548444)
 AA 713 60.8 686 61.5 1.00   0.021 0.041  
 AG 417 35.5 363 32.6 0.91 (0.76, 1.08)    
 GG 43 3.7 66 5.9 1.61 (1.08, 2.40)    
 AA/AG vs. GG 43 3.7 66 5.9 1.67 (1.12, 2.48)    Modifier
PRKRA (rs10207436)
 AA 616 52.5 655 58.7 1.00   0.013 0.026  
 AG 480 40.9 400 35.9 0.78 (0.66, 0.93)    
 GG 77 6.6 60 5.4 0.75 (0.52, 1.07)    
 AA vs. AG/GG 557 47.5 460 41.3 0.78 (0.66, 0.92)    Modifier
  1. a Adjusted for age, sex and center
  2. b These p-values are for the co-dominant model only
  3. c This SNP is predicted to have a ‘modifier’ effect for C5orf22 by VEP