|
Controls
|
Cases
| |
---|
N
|
%
|
N
|
%
|
OR
|
(95 % CI)
|
P-valuea,b
|
P Holmb
|
VEP Prediction
|
---|
AGO2 (rs6985156)
|
GG
|
912
|
77.7
|
858
|
77.0
|
1.00
| |
0.030
|
0.395
| |
GA
|
250
|
21.3
|
230
|
20.6
|
0.98
|
(0.80, 1.20)
| | | |
AA
|
11
|
0.9
|
27
|
2.4
|
2.59
|
(1.27, 5.26)
| | | |
GG/GA vs. AA
|
11
|
0.9
|
27
|
2.4
|
2.6
|
(1.28, 5.28)
| | |
Modifier
|
AGO2 (rs7843258)
|
CC
|
810
|
69.1
|
779
|
69.9
|
1.00
| |
0.031
|
0.395
| |
CT
|
342
|
29.2
|
298
|
26.7
|
0.90
|
(0.75, 1.08)
| | | |
TT
|
21
|
1.8
|
38
|
3.4
|
1.87
|
(1.09, 3.23)
| | | |
CC/CT vs.TT
|
21
|
1.8
|
38
|
3.4
|
1.93
|
(1.12, 3.32)
| | |
Modifier
|
AGO2 (rs2176397)
|
CC
|
567
|
48.3
|
568
|
50.9
|
1.00
| |
0.019
|
0.273
| |
CT
|
517
|
44.1
|
435
|
39.0
|
0.85
|
(0.71, 1.01)
| | | |
TT
|
89
|
7.6
|
112
|
10.0
|
1.26
|
(0.93, 1.71)
| | | |
CC/CT vs. TT
|
89
|
7.6
|
112
|
10
|
1.36
|
(1.02, 1.83)
| | |
Modifier
|
AGO2 (rs4961278)
|
AA
|
605
|
51.6
|
578
|
51.8
|
1.00
| |
0.032
|
0.395
| |
AG
|
501
|
42.7
|
444
|
39.8
|
0.92
|
(0.78, 1.09)
| | | |
GG
|
67
|
5.7
|
93
|
8.3
|
1.45
|
(1.04, 2.03)
| | | |
AA/AG vs. GG
|
67
|
5.7
|
93
|
8.3
|
1.51
|
(1.09, 2.09)
| | |
Modifier
|
BMP2 (rs3178250)
|
TT
|
747
|
63.7
|
663
|
59.5
|
1.00
| |
0.014
|
0.040
| |
TC
|
371
|
31.6
|
415
|
37.2
|
1.24
|
(1.04, 1.48)
| | | |
CC
|
55
|
4.7
|
37
|
3.3
|
0.75
|
(0.49, 1.16)
| | | |
TT vs.TC/CC
|
426
|
36.3
|
452
|
40.5
|
1.18
|
(0.99, 1.40)
| | |
Modifier
|
DGCR8 (rs11089328)
|
AA
|
400
|
34.1
|
432
|
38.7
|
1.00
| |
0.009
|
0.066
| |
AG
|
586
|
50.0
|
491
|
44.0
|
0.76
|
(0.63, 0.91)
| | | |
GG
|
187
|
15.9
|
192
|
17.2
|
0.94
|
(0.74, 1.20)
| | | |
AA vs. AG/GG
|
773
|
65.9
|
683
|
61.3
|
0.80
|
(0.68, 0.96)
| | |
Modifier
|
DROSHA (rs2287584)
|
TT
|
743
|
63.3
|
742
|
66.5
|
1.00
| |
0.032
|
0.384
| |
TC
|
394
|
33.6
|
325
|
29.1
|
0.82
|
(0.69, 0.99)
| | | |
CC
|
36
|
3.1
|
48
|
4.3
|
1.33
|
(0.85, 2.08)
| | | |
TT/TC vs. CC
|
36
|
3.1
|
48
|
4.3
|
1.42
|
(0.91, 2.20)
| | |
Low
|
DROSHA (rs17410035)
|
GG
|
552
|
47.1
|
468
|
42.0
|
1.00
| |
0.014
|
0.181
| |
GT
|
473
|
40.3
|
518
|
46.5
|
1.29
|
(1.08, 1.53)
| | | |
TT
|
148
|
12.6
|
129
|
11.6
|
1.01
|
(0.77, 1.32)
| | | |
GG vs. GT/TT
|
621
|
52.9
|
647
|
58.0
|
1.22
|
(1.03, 1.44)
| | |
Modifierc
|
GEMIN4 (rs2740348)
|
CC
|
782
|
66.7
|
798
|
71.6
|
1.00
| |
0.048
|
0.241
| |
CG
|
352
|
30.0
|
286
|
25.7
|
0.80
|
(0.67, 0.96)
| | | |
GG
|
39
|
3.3
|
31
|
2.8
|
0.78
|
(0.48, 1.27)
| | | |
CC vs. CG/GG
|
391
|
33.3
|
317
|
28.4
|
0.80
|
(0.67, 0.96)
| | |
Moderate
|
MAPKAPK2 (rs4548444)
|
AA
|
713
|
60.8
|
686
|
61.5
|
1.00
| |
0.021
|
0.041
| |
AG
|
417
|
35.5
|
363
|
32.6
|
0.91
|
(0.76, 1.08)
| | | |
GG
|
43
|
3.7
|
66
|
5.9
|
1.61
|
(1.08, 2.40)
| | | |
AA/AG vs. GG
|
43
|
3.7
|
66
|
5.9
|
1.67
|
(1.12, 2.48)
| | |
Modifier
|
PRKRA (rs10207436)
|
AA
|
616
|
52.5
|
655
|
58.7
|
1.00
| |
0.013
|
0.026
| |
AG
|
480
|
40.9
|
400
|
35.9
|
0.78
|
(0.66, 0.93)
| | | |
GG
|
77
|
6.6
|
60
|
5.4
|
0.75
|
(0.52, 1.07)
| | | |
AA vs. AG/GG
|
557
|
47.5
|
460
|
41.3
|
0.78
|
(0.66, 0.92)
| | |
Modifier
|
-
a Adjusted for age, sex and center
-
b These p-values are for the co-dominant model only
-
c This SNP is predicted to have a ‘modifier’ effect for C5orf22 by VEP