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Table 4 SNPs, previously identified as significantly associated with either mRNA expression or cancer after multiple comparisons, associated with miRNA expression at an FDR level of 0.10

From: Impact of polymorphisms in microRNA biogenesis genes on colon cancer risk and microRNA expression levels: a population-based, case-control study

SNP miRNA N Mean miRNA expression N Mean miRNA expression P-valuesd
Normal Colonic Mucosa
  AA/AG GG  
rs4548444 (MAPKAPK2)b hsa-miR-3163 376 9.46 25 11.35 0.0033
hsa-miR-378c 376 7.03 25 8.72 0.0084
hsa-miR-4316 376 6.74 25 8.22 0.0003
hsa-miR-4444 376 8.51 25 9.85 0.0035
hsa-miR-4753-5p 376 7.84 25 9.50 0.0059
hsa-miR-509-5p 376 7.73 25 9.35 0.0040
hsa-miR-5195-5p 376 8.24 25 10.16 0.0076
hsa-miR-659-3p 376 10.83 25 12.85 0.0095
hsa-miR-770-5p 376 5.93 25 7.11 0.0030
  TT TC/CC  
rs2740349 (GEMIN4)a hsa-miR-145-5p 280 184.32 121 229.78 0.0011
hsa-miR-378a-3p 280 145.01 121 163.22 0.0005
hsa-miR-378i 280 72.24 121 80.89 0.0013
hsa-miR-4428 280 1322.42 121 1442.51 0.0017
hsa-miR-451a 280 23.52 121 41.62 0.0021
hsa-miR-494 280 15338.94 121 16994.17 0.0013
  TT/TA AA  
rs235768 (BMP2)a hsa-miR-1321 357 4.89 44 6.17 0.0034
hsa-miR-206 357 10.43 44 12.25 0.0032
hsa-miR-23a-5p 357 5.98 44 6.61 0.0045
hsa-miR-30c-2-3p 357 4.70 44 5.51 0.0001
hsa-miR-3189-3p 357 6.49 44 7.27 0.0032
hsa-miR-4494 357 9.63 44 10.62 0.0021
hsa-miR-4648 357 9.00 44 9.99 0.0017
hsa-miR-4707-3p 357 8.05 44 9.75 0.0001
Differential (between carcinoma tissue and normal colonic mucosa)
  AA AG/GG  
rs11089328 (DGCR8)c hsa-miR-645 140 1.27 243 2.14 0.0002
  1. a SNP significantly associated with mRNA expression after correction for multiple comparisons
  2. b SNP significantly associated with cancer after correction for multiple comparisons
  3. c SNP associated with cancer, but not significantly after correction for multiple comparisons
  4. d Raw p-value