Impact of polymorphisms in microRNA biogenesis genes on colon cancer risk and microRNA expression levels: a population-based, case-control study

Table 4 SNPs, previously identified as significantly associated with either mRNA expression or cancer after multiple comparisons, associated with miRNA expression at an FDR level of 0.10

SNP	miRNA	N	Mean miRNA expression	N	Mean miRNA expression	P-values^d
Normal Colonic Mucosa
		AA/AG		GG
rs4548444 (MAPKAPK2)^b	hsa-miR-3163	376	9.46	25	11.35	0.0033
	hsa-miR-378c	376	7.03	25	8.72	0.0084
	hsa-miR-4316	376	6.74	25	8.22	0.0003
	hsa-miR-4444	376	8.51	25	9.85	0.0035
	hsa-miR-4753-5p	376	7.84	25	9.50	0.0059
	hsa-miR-509-5p	376	7.73	25	9.35	0.0040
	hsa-miR-5195-5p	376	8.24	25	10.16	0.0076
	hsa-miR-659-3p	376	10.83	25	12.85	0.0095
	hsa-miR-770-5p	376	5.93	25	7.11	0.0030
		TT		TC/CC
rs2740349 (GEMIN4)^a	hsa-miR-145-5p	280	184.32	121	229.78	0.0011
	hsa-miR-378a-3p	280	145.01	121	163.22	0.0005
	hsa-miR-378i	280	72.24	121	80.89	0.0013
	hsa-miR-4428	280	1322.42	121	1442.51	0.0017
	hsa-miR-451a	280	23.52	121	41.62	0.0021
	hsa-miR-494	280	15338.94	121	16994.17	0.0013
		TT/TA		AA
rs235768 (BMP2)^a	hsa-miR-1321	357	4.89	44	6.17	0.0034
	hsa-miR-206	357	10.43	44	12.25	0.0032
	hsa-miR-23a-5p	357	5.98	44	6.61	0.0045
	hsa-miR-30c-2-3p	357	4.70	44	5.51	0.0001
	hsa-miR-3189-3p	357	6.49	44	7.27	0.0032
	hsa-miR-4494	357	9.63	44	10.62	0.0021
	hsa-miR-4648	357	9.00	44	9.99	0.0017
	hsa-miR-4707-3p	357	8.05	44	9.75	0.0001
Differential (between carcinoma tissue and normal colonic mucosa)
		AA		AG/GG
rs11089328 (DGCR8)^c	hsa-miR-645	140	1.27	243	2.14	0.0002

^a SNP significantly associated with mRNA expression after correction for multiple comparisons
^b SNP significantly associated with cancer after correction for multiple comparisons
^c SNP associated with cancer, but not significantly after correction for multiple comparisons
^d Raw p-value

ISSN: 1755-8794