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Comparison of two high-throughput semiconductor chip sequencing platforms in noninvasive prenatal testing for Down syndrome in early pregnancy

  • Sunshin Kim1,
  • HeeJung Jung2,
  • Sung Hee Han3,
  • SeungJae Lee2,
  • JeongSub Kwon2,
  • Min Gyun Kim4,
  • Hyungsik Chu5,
  • Hongliang Chen6,
  • Kyudong Han7,
  • Hwanjong Kwak8,
  • Sunghoon Park8,
  • Hee Jae Joo8,
  • Byung Chul Kim9Email author and
  • Jong Bhak1, 9, 10, 11Email author
Contributed equally
BMC Medical GenomicsBMC series – open, inclusive and trusted20169:22

Received: 30 September 2015

Accepted: 18 April 2016

Published: 30 April 2016

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Open Peer Review reports

Pre-publication versions of this article are available by contacting

Original Submission
30 Sep 2015 Submitted Original manuscript
15 Dec 2015 Reviewed Reviewer Report - John Williams
13 Jan 2016 Reviewed Reviewer Report - Tuangsit Wataganara
13 Feb 2016 Author responded Author comments - Sunshin Kim
Resubmission - Version 2
13 Feb 2016 Submitted Manuscript version 2
9 Mar 2016 Reviewed Reviewer Report - John Williams
2 Apr 2016 Author responded Author comments - Sunshin Kim
Resubmission - Version 3
2 Apr 2016 Submitted Manuscript version 3
18 Apr 2016 Editorially accepted
30 Apr 2016 Article published 10.1186/s12920-016-0182-9

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting

You can find further information about the peer review system here.

Authors’ Affiliations

GenomeCare, Suwon, Republic of Korea
Mirae & Heemang OB/GYN Clinic, Seoul, Republic of Korea
Seoul Clinical Laboratories (SCL), Yongin, Republic of Korea
Namujungwon Maternity Hospital, Yangju, Republic of Korea
GN Maternity Hospital, Pyeongtak, Republic of Korea
Xiamen Vangenes BioTech, Xiamen, China
Department of Nanobiomedical Science, BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea
TheragenEtex, Suwon, Republic of Korea
The Genomics Institute (TGI), BioMedical Engineering, UNIST, Ulsan, Republic of Korea
Geromics, Ulsan, Republic of Korea
Genome Research Foundation, Osong, Republic of Korea