Table 1 Key elements of information sets

Information Set 1. The idea of genomic profiling

 • Description of colorectal cancer/newborn bloodspot screening program

 • Genomic profiling test (referred to as ‘DNA risk test’) and how this could be used implemented

 • Emphasis on the technology and improvement on current approaches, and potential benefits e.g. reducing unnecessary interventions and targeting interventions to those most at risk

Information Set 2. The potential personal impacts of having a test

 • Potential advantages: lifestyle choices, screening participation, attending promptly to early symptoms; personal utility of knowledge irrespective of potential for risk reduction

 • Potential disadvantages: anxiety, depression, disease worry, reduced quality of life (if higher risk); failure to follow health advice, neglect of early symptoms (if lower risk)

 • Potential for effects on others: e.g. family members, as well access and use by third parties (e.g. insurance companies)

 • Idea that results are not transient but ‘for life’

Information Set 3. Reiteration of the nature of such a test, and its place in personal health management

 • Integration of genomic profiling within broader set of risk assessment and screening tests

 • Reinforcement of risk not actual disease status conferred by the tests