Table 1 Notations
From: Inferring Crohn’s disease association from exome sequences by integrating biological knowledge
Notation | Definition |
|---|---|
n | Number of amino acid substitutions |
m | Number of exomes |
l | Number of genes |
l D | Number of known Crohn’s disease genes |
V | Exome matrix (n×m) |
P | Pathogenicity of amino acid substitutions (n×l) |
W | Disease-gene association matrix (l×2) |
H | Disease-exome association matrix (2×m) |
M | Gene-gene interaction network (l×l) |
P 0 | Pathogenicity prediction by PolyPhen-2 (n×l) |
W 0 | Annotated Crohn’s disease-gene association matrix (l×2) |
v | Indicator vector for known Crohn’s disease genes (l) |
r | Crohn’s disease association vector derived from W (l) |