Integration of bioinformatics and imaging informatics for identifying rare PSEN1 variants in Alzheimer’s disease

Table 4 Gene-based association results (p-values) for imaging biomarkers (entorhinal cortical thickness (EntCtx)) using rare variants (MAF < 0.0257)

	Burden	SKAT-O	SKAT-O after adjusting for APOE ε4 status
Left EntCtx	0.009	0.015	0.010
Right EntCtx	0.027	0.046	0.032

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