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Table 3 Comparison of gene expression between resistant and non-resistant cell lines for adenocarcinoma and squamous cell carcinoma [65], and H3K9K14ac during treatment with an HDAC inhibitor for NSCLC cell lines [85]

From: SFRP1 is a possible candidate for epigenetic therapy in non-small cell lung cancer

Gene expression
Adenocarcinoma
   P-value Non-resistant cell lines resistant cell lines
 SFRP1   4.64 × 10 −4 611.06 >92.60
 DKK3   6.73 × 10−2 263.27 >30.59
Squamous cell carcinoma
 SFRP1   7.42 × 10 −3 304.53 >49.53
 DKK3   4.61 × 10−1 261.38 <506.25
Histone modification (H3K9K14ac)
   P-value 0 hours 2 hours
  (A549) 2.90 × 10 −2 −1.29 <−0.52
 SFRP1 (H1299) 4.06 × 10 −2 −2.51 <−1.85
  (CL1-1) 8.71 × 10−1 −1.38 <−1.34
  (A549) 6.19 × 10−1 −1.17 <−1.01
 DKK3 (H1299) 1.98 × 10 −3 −1.70 <−0.48
  (CL1-1) 1.48 × 10−1 −0.59 >−1.13
  (A549) 4.74 × 10−1 −1.70 <−1.37
 TACSTD1 (H1299) 1.51 × 10−1 −2.61 <−2.20
  (CL1-1) 8.62 × 10−1 −2.03 >−2.09
  (A549) 1.71 × 10 −3 −2.44 <−1.05
 SALL4 (H1299) 5.23 × 10−1 −2.62 >−2.86
  (CL1-1) 1.03 × 10 −4 0.97 >−0.59
  1. Significant P-values (<0.05) are shown in bold