Fig. 3
From: Frequent hypermethylation of orphan CpG islands with enhancer activity in cancer
eCGIs are a distinct class of enhancers that regulate target gene expression. a The left panel is an example of a cell-type-specific eCGI target, demonstrated using the WashU epigenome browser. The yellow shaded region indicates K562-specific eCGIs and the green shaded region represents their target gene, NFIA. The right panel compares the gene expression level (RPKM) of NFIA in K562 and Mcf7 cell lines. b The diagram shows overlapping between eCGIs and npCGIs in K562 and Mcf7 cell lines. c Expression fold change of genes targeted by each cell-type-specific eCGI. d ChIA-pet signal distribution in K562 (left) and Mcf7 (right) cell lines. The P-value was calculated by the Wilcoxon signed-rank test. e Histogram showing the proportion of enhancers targeting one gene (single) and two or more genes (multiple)