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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Frequent hypermethylation of orphan CpG islands with enhancer activity in cancer

Fig. 4

eCGIs primarily target transcription regulators. a The gene clusters with the highest enrichment score detected by the DAVID’s functional annotation clustering in K562 (left) and Mcf7 (right). P values were transformed by –log10. All clustering lists are provided in Additional file 1: Table S2. b, c The distribution of the number of transcription regulators associated with random DNA fragments (black line). The permutation was repeated 1000 times. Red lines indicate the number of transcription regulators associated with the eCGIs (upper) or typical enhancers (lower) in K562 (B) and in Mcf7 (C)

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