- The novel candidate genes identified in this cohort were ranked from most likely (red) to less (green) based on the scores using the following criteria: a. Genes found in multiple families with similar phenotypes (3 points); b. Interactors/paralogs of the gene showing overlapping features in human (2 points); c. Animal studies of the gene or its interactor/paralogs showing overlapping features (2 points); d. Genomic region associated with the phenotypes (1 point); e. Loss-of-function variant (2 points); f. Predicted deleterious by multiple programs (1 point); g. Rare variants in multiple databases (1 point); h. Expressed in the tissues/organs being affected (1 point). DD/ID: Developmental Delay/Intellectual Disability; ADHD: attention deficit hyperactivity disorder; PFO: Patent foramen ovale; VSD: Ventricular Septal Defect; VUR: Vesicoureteral Reflux; Hom: homozygous; Het: heterozygous; cHet: compound heterozygous; Hem: hemizygous