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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Dealing with prognostic signature instability: a strategy illustrated for cardiovascular events in patients with end-stage renal disease

Fig. 1

Strategy building blocks for investigating and improving signature stability. All steps are based on resampling data sets, which serve as a foundation. Subsequent steps involving all model building steps, e.g. cross-validation for model complexity selection, are indicated in white, steps based on fixed complexity levels in gray. Of the latter, steps for identifying outliers are indicated by light gray, steps for investigating different modeling strategies are indicated by darker gray shading

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