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Table 4 Comparative association status of known tag SNPs (Monsur et al., [21], Romanos et al., [11] and [12]) for DQ haplotypes

From: Shared and unique common genetic determinants between pediatric and adult celiac disease

HLA alleles Risk allele (RA) Risk allele frequency P-value OR CD groups
Indian African European
HLA-DQ2.2 (rs2395182) T 0.83 0.73 0.76 1.06 × 10−5 2.72 [1.74–4.25] Pediatric
6.26 × 10−5 1.99 [1.42–2.79] Adult
HLA-DQ2.2 (rs7775228) T 0.73 0.83 0.85 1.14 × 10−4 1.89 [1.36–2.63] Pediatric
5.08 × 10−7 2.12 [1.58–2.84] Adult
HLA-DQ2.5 (rs2187668) A 0.16 0.06 0.10 3.46 × 10−28 6.03 [4.38–8.30] Pediatric
2.45 × 10−34 5.99 [4.49–7.98] Adult
HLA-DQ8 (rs7454108) T 0.94 0.97 0.89 0.08 1.72 [0.93–3.18] Pediatric
0.20 1.37 [0.84–2.22] Adult
HLA-DQ4 (rs4713586) T 0.98 0.92 0.94 0.03 9.05 [1.18–69.50] Pediatric
0.03 3.71 [1.18–11.78] Adult
  1. Genotype data for SNP (rs4639334) tagging -DQ7 haplotype was not present in the dataset and therefore was not available for the study