Table 4 Comparative association status of known tag SNPs (Monsur et al., [21], Romanos et al., [11] and [12]) for DQ haplotypes
From: Shared and unique common genetic determinants between pediatric and adult celiac disease
HLA alleles | Risk allele (RA) | Risk allele frequency | P-value | OR | CD groups | ||
|---|---|---|---|---|---|---|---|
Indian | African | European | |||||
HLA-DQ2.2 (rs2395182) | T | 0.83 | 0.73 | 0.76 | 1.06 × 10−5 | 2.72 [1.74–4.25] | Pediatric |
6.26 × 10−5 | 1.99 [1.42–2.79] | Adult | |||||
HLA-DQ2.2 (rs7775228) | T | 0.73 | 0.83 | 0.85 | 1.14 × 10−4 | 1.89 [1.36–2.63] | Pediatric |
5.08 × 10−7 | 2.12 [1.58–2.84] | Adult | |||||
HLA-DQ2.5 (rs2187668) | A | 0.16 | 0.06 | 0.10 | 3.46 × 10−28 | 6.03 [4.38–8.30] | Pediatric |
2.45 × 10−34 | 5.99 [4.49–7.98] | Adult | |||||
HLA-DQ8 (rs7454108) | T | 0.94 | 0.97 | 0.89 | 0.08 | 1.72 [0.93–3.18] | Pediatric |
0.20 | 1.37 [0.84–2.22] | Adult | |||||
HLA-DQ4 (rs4713586) | T | 0.98 | 0.92 | 0.94 | 0.03 | 9.05 [1.18–69.50] | Pediatric |
0.03 | 3.71 [1.18–11.78] | Adult | |||||