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Table 3 Univariate and multivariate cox proportional hazard regression analyses

From: A 19-Gene expression signature as a predictor of survival in colorectal cancer

Genes

Univariate

Multivariate

 

Hazard ratio (95 % CI)

p-value

Hazard ratio (95 % CI)

p-value

NOTCH2

1.356 (1.154 – 1.592)

0.000 ***

1.56 (1.034 – 1.913)

0.009 **

ITPRIP

1.063 (0.919 – 1.23)

0.408

0.852 (0.614 – 1.183)

0.340

FRMD6

1.259 (1.092 – 1.452)

0.001 **

1.066 (0.850 – 1.338)

0.575

GFRA4

0.860 (0.728 – 1.016)

0.005 **

0.871 (0.547 – 1.005)

0.010 **

OSBPL9

0.803 (0.671 – 0.962)

0.017 **

0.818 (0.640 – 1.045)

0.047 **

CPXCR1

0.918 (0.811 – 1.041)

0.183’

1.030 (0.766 – 1.387)

0.840

SORCS2

1.159 (1.041 – 1.290)

0.006 **

0.936 (0.752 – 1.166)

0.558

PDC

0.812 (0.679 – 0.970)

0.022 **

1.068 (0.796 – 1.432)

0.659

C12orf66

0.902 (0.808 – 1.008)

0.069 *

1.007 (0.729 – 1.390)

0.965

SLC38A9

0.919 (0.845 – 1.000)

0.050 *

1.073 (0.894 – 1.289)

0.443

OR10H5

0.846 (0.704 – 1.018)

0.075 *

1.078 (0.826 – 1.407)

0.579

TRIP13

0.881 (0.802 – 0.968)

0.008 **

0.985 (0.780 – 1.244)

0.901

MRPL52

0.848 (0.767 – 0.939)

0.001 **

0.865 (0.697 – 1.075)

0.019 **

DUSP21

0.903 (0.807 – 1.011)

0.077 *

0.928 (0.697 – 1.235)

0.609

BRCA1

0.836 (0.764 – 0.915)

0.000 ***

0.884 (0.713 – 1.097)

0.264

ELTD1

1.155 (1.021 – 1.307)

0.021 **

0.969 (0.772 – 1.216)

0.787

SPG7

1.141 (1.035 – 1.259)

0.008 **

1.026 (0.840 – 1.255)

0.797

LASS6

0.867 (0.782 – 0.961)

0.006 **

0.788 (0.631 – 0.984)

0.035 **

DUOX2

1.076 (0.975 – 1.187)

0.141’

1.039 (0.844 – 1.280)

0.715

Age (>60)

0.154 (0.01953 – 1.225)

0.045 **

0.562 (0.0354 – 2.392)

0.049 **

Gender

1.048 (0.554 – 1.981)

0.886

1.729 (0.704 – 4.245)

0.231

Stage

1.644 (0.8567 – 3.156)

0.135’

1.274 (0.494 – 3.286)

0.615

  1. This table shows the univariate and multivariate cox proportional hazard regression analyses of 19 gene signatures and other clinical variables associated with overall survival of CRC patients. [Relevant location: Page 14]