Table 4 Comparison the LASSO and Ridge regression methods with Elastic Net regression
From: A 19-Gene expression signature as a predictor of survival in colorectal cancer
| Â | Univariate | Multivariate | |||
|---|---|---|---|---|---|
| Â | HR (95Â % CI) | P | HR (95Â % CI) | P | |
Datasets | Methods | Â | Â | Â | Â |
Lasso | 0.106 (0.030 – 0.370) | 0.000 | 0.063 (0.016 – 0.252) | 0.000 | |
Our dataset | Ridge | 0.812 (0.303 – 2.173) | 0.000 | 0.083 (0.022 – 0.321) | 0.000 |
Elastic net | 0.065 (0.014 – 0.287) | 0.000 | 0.040 (0.008 – 0.198) | 0.000 | |
Denmark dataset | Lasso | 0.055 (0.007 – 0.453) | 0.007 | 0.044 (0.005 – 0.396) | 0.005 |
Ridge | 0.112 (0.024 – 0.519) | 0.005 | 0.080 (0.014 – 0.467) | 0.005 | |
Elastic net | 0.057 (0.007 – 0.464) | 0.007 | 0.038 (0.004 – 0.389) | 0.005 | |
Australian dataset | Lasso | 0.565 (0.396 – 0.805) | 0.002 | 0.549 (0.384 – 0.784) | 0.001 |
Ridge | 0.447 (0.312 – 0.641) | 0.000 | 0.454 (0.316 – 0.651) | 0.000 | |
Elastic net | 0.523 (0.370 – 0.739) | 0.000 | 0.529 (0.373 – 0.748) | 0.000 | |
USA dataset | Lasso | 0.105 (0.010 – 1.068) | 0.056 | 0.104 (0.010 – 1.052) | 0.055 |
Ridge | 0.130 (0.013 – 1.294) | 0.082 | 0.129 (0.013 – 1.283) | 0.081 | |
Elastic net | 0.120 (0. 012 – 1.195) | 0.071 | 0. 122 (0. 012 – 1.214) | 0. 072 | |
Norway dataset | Lasso | --- | --- | --- | --- |
Ridge | --- | --- | --- | --- | |
Elastic net | 0.536 (0.300 – 0.957) | 0.035 | 0.569 (0.318 – 1.018) | 0.057 | |