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Table 1 Top canonical pathways enriched for differentially regulated genes. Top Canonical Pathways identified for the gene lists identified through the Binning and Scaling methods of normalisation across studies

From: A meta-analysis of public microarray data identifies gene regulatory pathways deregulated in peripheral blood mononuclear cells from individuals with Systemic Lupus Erythematosus compared to those without

Top Canonical Pathway Binning method Scaling method
p-value Ratio p-value Ratio
Agranulocyte Adhesion and Diapedesis 1.59 × 10-05 § 19/190 (0.1)§ 1.37 × 10-04 § 15/190 (0.079)§
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses 7.11 × 10-05 § 14/127 (0.11)§ 1.18 × 10-04 § 12/127 (0.094)§
Role of Cytokines in Mediating Communication between Immune Cells 2.23 × 10−03 (0.13) 1.27 × 10-05 § 9/56 (0.161)§
Role of Hypercytokinemia/Hyperchemokinemia in the Pathogenesis of Influenza 3.24 × 10−03 (0.13) 1.8 × 10-05 § 8/45 (0.178)§
Interferon Signaling 9.58 × 10-05 § 7/34 (0.206) § 2.14 × 10−04 0.18
Oxidative Phosphorylation 1.4 × 10-04 § 13/119 (0.109) § 0.197 0.042
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis 1.10 × 10−03 0.07 1.45 × 10-04 § 20/304 (0.066)§
Toll-like Receptor Signaling 6.67 × 10-04 § 9/74 (0.122) § 3.02 × 10−03 0.095
  1. §indicates the top five pathways for each method; the ratio represents the number of involved genes divided by the total number of genes in the pathway; the p-value indicates over-representation of genes in the pathway