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Table 3 Top upstream regulators for differentially regulated genes. Top upstream regulators, shown by HUGO gene symbols, identified by IPA for the gene lists identified through the Binning and Scaling methods of normalisation across studies

From: A meta-analysis of public microarray data identifies gene regulatory pathways deregulated in peripheral blood mononuclear cells from individuals with Systemic Lupus Erythematosus compared to those without

Top Upstream Regulators p-value
Binning method Scaling method
IFNL1 2.20 × 10−21 4.06 × 10−21
IFNA2 1.87 × 10−20 3.13 × 10−18
Tretinoin 2.55 × 10−17 1.70 × 10-11 ¥
TNF 4.33 × 10−14 8.91 × 10−13
IRF7 5.85 × 10−14 1.40 × 10−13
IRF3 1.99 × 10-8 ¥ 1.24 × 10−12
  1. ¥indicates p-values that do not fall in the top five