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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Epigenetic profiling of human brain differential DNA methylation networks in schizophrenia

Fig. 3

The differential methylation network of schizophrenia. The schizophrenic differential methylation network (SDMN) was generated by QQPPI of schizophrenic differential methylated genes (SDMGs) with underlying pathway enrichment. Among those SDMGs, there are 10 hypermethylated promoters in SDMN including GNA13, CAPNS1, GABPB2, GIT2, LEFTY1, NDUFA10, MIOS, MPHOSPH6, PRDM14 and RFWD2. They represent the key roles in modulating specific regulatory functions in schizophrenia. The thick lines represent the protein-protein interactions, the thin lines are binary relations (such as biochemical reactions) between genes in Pathway Commons. The zig-zag lines stand for both protein-protein interactions and binary relations. The green and red nodes stand for hypo- and hypermethylated genes respectively. The yellow nodes are depicted as hypermethylated promoters. The V-arrow nodes are depicted as under-expression genes and the triangular nodes are depicted as over-expression genes

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