Fig. 4

Hypermethylation to differential expression network. The hypermethylation to differential expression network (HyDEN) was constructed by hypermethylated promoters, SCZCGs and their Level one PPIs. The schizophrenic hypermethylated promoters, which interacting with differential expression genes, indicate the majority of hypermethylated genes suppressed the expression SCZCGs. The red triangular nodes are depicted as over-expressed genes and the green rectangle nodes are depicted as under-expressed genes, the yellow eclipse nodes are hypermethylated genes. The thick lines are PPIs. The thin lines are binary relations (e.g. biochemical reactions) between genes listed in Pathway Commons Databases