Fig. 5
From: Epigenetic profiling of human brain differential DNA methylation networks in schizophrenia
The ribosome-associated PPI network. The ribosome-associated PPI network constructed with SDMGs and SCZCGs revealed the regulatory role of epigenetic mechanism in schizophrenia. The red and green nodes are depicted as over- and under-expressed SCZCGs, respectively. The purple nodes are hypomethylated promoters. The ribosome biosynthesis is likely to be regulated by hypomethylated SDMGs which interacts with differentially expressed SCZCGs. The regulation of ribosome expression by the hypomethylated promoters may be crucial in the pathogenesis for schizophrenia