Fig. 10

Mapping co-mutation sites detected onto HA1 protein of flu B/Yamagata (PDB ID: 4NRJ [42]). The red, blue, cyan and green colors represent 120-loop, 150-loop, 160-loop and 190-helix respectively. The four clusters have been found to cause antigenicity variation, together forming a single large antigenic site with overlapping epitopes. The co-mutation sites are circled and marked with corresponding numbers