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Table 1 Methylation sites associated with oxidative markers in blood

From: DNA methylation patterns associated with oxidative stress in an ageing population

Phenotype Number Mean (SD) Range No. of CpG sites associated at FDR <0.05 No. of CpG sites associated at P-value <1.1E-7
TGSH (μg/ml) 958 905.0 (199.3) 440–1836 18 3
GSH (μg/ml) 957 829.9 (191.1) 398–1730 25 2
GSSG (μg/ml) 959 75.8 (35.7) 23–257 1 1
GSSG/GSH ratio 957 0.1 (0.06) 0.03–0.53 21 3
HCY (μmol/l) 966 10.6 (3.98) 3.4–40.7 9 6
ln OxLDL (U/l) 966 132.8 (47.7) 42–285 1 1
CD (μmol/l) 966 40.7 (11.1) 13.8–90.4 1 1
BCD-LDL (μmol/l) 964 21.7 (7.4) 7.8–71.7 6 4
ln OLAB (U/l) 734 5.9 (0.96) 3.4–7.9 0 0
TAOC (%) 957 37.6 (3.9) 22–55 0 0
  1. SD standard deviation, CpG cytosine-guanine site, FDR false discovery rate, TGSH total glutathione level, GSH reduced glutathione, GSSG oxidised glutathione, HCY homocysteine, OxLDL oxidised LDL, CD conjugated dienes, BCD baseline CD, OLAB antibodies against oxLDL, TAOC total antioxidant capacity