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Table 1 Methylation sites associated with oxidative markers in blood

From: DNA methylation patterns associated with oxidative stress in an ageing population

Phenotype

Number

Mean (SD)

Range

No. of CpG sites associated at FDR <0.05

No. of CpG sites associated at P-value <1.1E-7

TGSH (μg/ml)

958

905.0 (199.3)

440–1836

18

3

GSH (μg/ml)

957

829.9 (191.1)

398–1730

25

2

GSSG (μg/ml)

959

75.8 (35.7)

23–257

1

1

GSSG/GSH ratio

957

0.1 (0.06)

0.03–0.53

21

3

HCY (μmol/l)

966

10.6 (3.98)

3.4–40.7

9

6

ln OxLDL (U/l)

966

132.8 (47.7)

42–285

1

1

CD (μmol/l)

966

40.7 (11.1)

13.8–90.4

1

1

BCD-LDL (μmol/l)

964

21.7 (7.4)

7.8–71.7

6

4

ln OLAB (U/l)

734

5.9 (0.96)

3.4–7.9

0

0

TAOC (%)

957

37.6 (3.9)

22–55

0

0

  1. SD standard deviation, CpG cytosine-guanine site, FDR false discovery rate, TGSH total glutathione level, GSH reduced glutathione, GSSG oxidised glutathione, HCY homocysteine, OxLDL oxidised LDL, CD conjugated dienes, BCD baseline CD, OLAB antibodies against oxLDL, TAOC total antioxidant capacity