Fig. 1From: Genetic study of congenital bile-duct dilatation identifies de novo and inherited variants in functionally related genesDistribution of constraint scores of all genes with de novo non-synonymous variants. Y axis: number of genes whose constrain scores fall into the range specified in the X axis. X axis: constrain scores as defined by Samocha et al. [16]. (The genes with constraint score > 3.09 are highly constrained, corresponding to P < 0.001 and represented roughly 5% of all genes.)Back to article page