A.
|
Type
|
Sex
|
Pooled-DNA GWAS
|
Enrolled (Set I)
|
Enrolled (Set II)
|
Na
|
Age, range (years)
|
Median age (years)
|
Nb
|
Age, range (years)
|
Median age (years)
|
PSC
|
Females
|
40
|
12–61
|
31
|
37
|
17–52
|
31
|
Males
|
80
|
9–64
|
26
|
74
|
9–49
|
26
|
All
|
120
|
9–64
|
29
|
111
|
9–52
|
28
|
PBC
|
Females
|
420
|
14–85
|
53
|
407
|
29–80
|
53
|
Males
|
0
|
0
|
0
|
0
|
0
|
0
|
|
420
|
14–85
|
53
|
407
|
29–80
|
53
|
Healthy controls
|
Females
|
363
|
3–88
|
55
|
222
|
25–65
|
43
|
Males
|
361
|
3–69
|
22
|
148
|
28–65
|
47
|
All
|
724
|
3–88
|
50
|
370
|
25–65
|
44
|
B.
|
Type
|
Sex
|
Individual patient genotyping
|
Enrolled
|
N
|
Age, range (years)
|
Median age (years)
|
PSC
|
Females
|
41
|
17–52
|
31
|
Males
|
98
|
9–64
|
26
|
All
|
139
|
9–64
|
29
|
PBC
|
Females
|
443
|
14–85
|
54
|
Males
|
0
|
0
|
0
|
|
443
|
14–85
|
54
|
Healthy controls
|
Females
|
512
|
23–75
|
48
|
Males
|
422
|
27–78
|
48
|
All
|
934
|
23–78
|
47
|
- Panels indicate the number of patients enrolled in the GWAS (Na) after excluding microarrays that did not meet quality control criteria based on principal component analysis results (Nb) that included validation and replication analyses performed using respective individual patient TaqMan genotyping (N). The range and median values are the ages of cases and controls in the respective groups in years