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Table 1 Summary of the main epidemiological variables for the pooled-DNA allelotyping GWASs (A) and validation cohorts (B)

From: A novel approach to genome-wide association analysis identifies genetic associations with primary biliary cholangitis and primary sclerosing cholangitis in Polish patients

A.
Type Sex Pooled-DNA GWAS
Enrolled (Set I) Enrolled (Set II)
Na Age, range (years) Median age (years) Nb Age, range (years) Median age (years)
PSC Females 40 12–61 31 37 17–52 31
Males 80 9–64 26 74 9–49 26
All 120 9–64 29 111 9–52 28
PBC Females 420 14–85 53 407 29–80 53
Males 0 0 0 0 0 0
  420 14–85 53 407 29–80 53
Healthy controls Females 363 3–88 55 222 25–65 43
Males 361 3–69 22 148 28–65 47
All 724 3–88 50 370 25–65 44
B.
Type Sex Individual patient genotyping
Enrolled
N Age, range (years) Median age (years)
PSC Females 41 17–52 31
Males 98 9–64 26
All 139 9–64 29
PBC Females 443 14–85 54
Males 0 0 0
  443 14–85 54
Healthy controls Females 512 23–75 48
Males 422 27–78 48
All 934 23–78 47
  1. Panels indicate the number of patients enrolled in the GWAS (Na) after excluding microarrays that did not meet quality control criteria based on principal component analysis results (Nb) that included validation and replication analyses performed using respective individual patient TaqMan genotyping (N). The range and median values are the ages of cases and controls in the respective groups in years