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Table 3 BRCA variations found and their evaluations in BRCA databases

From: Next-generation sequencing in familial breast cancer patients from Lebanon

Gene Variation BIC database Clinically Importance/ Clinical Classification COSMIC Leiden Open Variation Database (LOVD) BRCA Exchange
BRCA1 c.G131T p.C44F unknown/ pending Not found Affects function Not found
c.A536G p.Y179C unknown/ pending Not found Does not affect function Benign
c.C4327T p.R1443* yes/ class 5 Neutral Affects function Not found
c.A1067G p.Q356R unknown/ pending Pathogenic Does not affect function Benign
c.5090_5093delGTTA p.L1697fs Not found Not found Not found Not found
BRCA2 c.C65T p.A22V unknown/pending Not found Effect unknown Not found
c.G223C p.A75P unknown/ pending Not found Does not affect function Benign
c.658_659delGT p.V220I* yes/ class 5 Not found Affects function Not found
c.C4061T p.T1354M unknown/ pending Neutral Does not affect function Benign
c.G4258T p.D1420Y no/ pending Neutral Does not affect function Benign
c.C5744T p.T1915M no/ class 1 Neutral Does not affect function Not found
c.G8775C p.Q2925H unknown/ pending Not found Effect unknown Not found
c.A1114C p.N372H no/ class 1 Neutral Not found Benign
c.C1151T p.S384F no/ pending Not found Not found Benign
  1. Descriptions of the classes in the BIC database:
  2. Class 1: Not pathogenic/low clinical significance: There is significant evidence against this variant being a dominant high-risk pathogenic mutation
  3. Class 5: Pathogenic: There is significant evidence to suggest that this variant is a dominant high-risk pathogenic mutation