Table 2 Top hypo- and hypermethylated sites between ME/CFS and healthy controls
Probe ID | Targeted gene symbol | Mean Beta-value (ME/CFS) | Mean Beta-value (control) | Beta-difference | p-value | Adjusted p-value (FDR) | Genic region | Relation to CpG Island |
|---|---|---|---|---|---|---|---|---|
cg26341831 | TMEM63A | 0.352 | 0.504 | -0.152 | 9.04e-4 | 1.05e-2 | Body | Open Sea |
cg00446123 | LIME1 | 0.340 | 0.478 | -0.138 | 1.17e-3 | 1.18e-2 | TSS200 | N Shore |
cg27058497 | RUNX3 | 0.314 | 0.450 | -0.136 | 7.60e-4 | 9.88e-3 | TSS200 | Open Sea |
cg08817540 | HHLA2 | 0.390 | 0.524 | -0.134 | 5.34e-4 | 8.92e-3 | TSS1500 | Open Sea |
cg17587997 | FYN | 0.529 | 0.663 | -0.134 | 8.66e-4 | 1.04e-2 | 5'UTR | Open Sea |
cg00660167 | N/A | 0.754 | 0.581 | 0.174 | 5.58e-4 | 9.03e-3 | N/A | N Shore |
cg23189692 | EIF4G1 | 0.652 | 0.486 | 0.166 | 5.10e-4 | 8.81e-3 | Gene Body | N Shelf |
cg17344770 | C19orf71 | 0.674 | 0.511 | 0.163 | 2.00e-4 | 8.16e-3 | TSS1500 | Open Sea |
cg07302959 | FAM133B | 0.664 | 0.503 | 0.161 | 9.04e-4 | 1.06e-2 | Gene Body | Open Sea |
cg06633438 | MLLT1 | 0.626 | 0.466 | 0.160 | 1.65e-4 | 8.16e-3 | Gene Body | Island |