Epigenetic modifications and glucocorticoid sensitivity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Table 4 Epigenetic loci associated with GC sensitivity in ME/CFS

Probe ID	Targeted gene symbol	Mean Beta-value (ME/CFS GC-Hypersensitive)	Mean Beta-value (ME/CFS GC-Typical)	Mean Beta-value (control)	Genic region
cg03484234	PNPLA4	0.595	0.525	0.536	TSS1500
cg04072270	N/A	0.651	0.708	0.715	N/A
cg04438194	N/A	0.199	0.134	0.147	N/A
cg05123845	N/A	0.546	0.601	0.605	N/A
cg05252487	FAM24A	0.289	0.354	0.344	5' UTR
cg05376982	GSTM5	0.609	0.498	0.479	TSS200
cg11680055	GSTM1	0.440	0.318	0.276	TSS200
cg12042203	N/A	0.672	0.618	0.620	N/A
cg14507445	N/A	0.833	0.776	0.773	N/A
cg15059639	MYO3B	0.762	0.636	0.614	Body
cg19196401	DDO	0.520	0.615	0.598	Body
cg19251564	N/A	0.711	0.660	0.654	N/A
cg19763428	PDE1C	0.420	0.362	0.349	Body

Thirteen differentially methylated sites that are associated with glucocorticoid sensitivity in ME/CFS GC-Hypersensitive subjects

ISSN: 1755-8794