Table 1 Functional distribution of 1153 p53-related genes analyzed by bioinformatics
| Â | Number of genes |
|---|---|
P53-related functional outcomes- | |
 apoptosis | 131 |
 cell cycle | 103 |
 DNA repair | 49 |
 oxidative stress | 25 |
 metabolism | 58 |
 nervous system | 17 |
 cytokines and inflammation | 36 |
 cytoskeleton/structural | 41 |
 extracellular matrix | 29 |
 senescence | 17 |
 hypoxia | 9 |
 nuclear receptors | 8 |
 localization | 4 |
 other | 84 |
Regulation of p53 by | |
 transcription machinery/translation | 110 |
 transcriptional activators | 53 |
 transcriptional repressors | 36 |
 chaperons | 13 |
 ubiquitination | 48 |
 deubiquitination | 7 |
 phosphorylation | 21 |
 dephosphorylation | 8 |
 acetylation | 16 |
 deacetylation | 20 |
 methylation | 8 |
 sumoylation | 14 |
 neddylation | 3 |
 isomerization | 3 |
 Other pathways related to p53 | 138 |
 KEGG | 44 |
 Total | 1153 |