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Table 1 Functional distribution of 1153 p53-related genes analyzed by bioinformatics

From: Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia

  Number of genes
P53-related functional outcomes-
 apoptosis 131
 cell cycle 103
 DNA repair 49
 oxidative stress 25
 metabolism 58
 nervous system 17
 cytokines and inflammation 36
 cytoskeleton/structural 41
 extracellular matrix 29
 senescence 17
 hypoxia 9
 nuclear receptors 8
 localization 4
 other 84
Regulation of p53 by
 transcription machinery/translation 110
 transcriptional activators 53
 transcriptional repressors 36
 chaperons 13
 ubiquitination 48
 deubiquitination 7
 phosphorylation 21
 dephosphorylation 8
 acetylation 16
 deacetylation 20
 methylation 8
 sumoylation 14
 neddylation 3
 isomerization 3
 Other pathways related to p53 138
 KEGG 44
 Total 1153
  1. The genes were categorized by functional outcomes of p53 pathway and factors that regulate it