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Table 2 The number of analyzed patients and revealed p53-related DEGs in 27 AML subtypes

From: Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia

AML subtypes Number of patients included in analysis Number of p53-related DEGs
Cytogenetic groups
 Normal 290 147*
 t (15;17) 34 172*
 t (8;21) 39 202*
 inv (16) 37 147*
 11q23 10 165*
 -5/7 (q) 31 102*
 trisomy 8 26 109*
 Complex 23 104*
 t (6;9) 5 176*
 t (9;22) 3 78
 -9(q) 7 88
FAB groups
 M0 48 145*
 M1 136 90*
 M2 157 37
 M3 34 172*
 M4 108 39
 M4E 5 185*
 M5 110 68*
 M6 9 42
Molecular mutations
 FLT3-ITD 132 128*
 FLT3-TKD 46 64
 NPM1 154 151*
 CEBPA 33 97
 NRAS 44 143*
 KRAS 4 171*
 EV1 28 163*
 RUNX1 11 143*
Total number of patients 607  
  1. *significant enrichment (p-value <0.01) for p53 pathway-related genes