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Table 2 The number of analyzed patients and revealed p53-related DEGs in 27 AML subtypes

From: Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia

AML subtypes

Number of patients included in analysis

Number of p53-related DEGs

Cytogenetic groups

 Normal

290

147*

 t (15;17)

34

172*

 t (8;21)

39

202*

 inv (16)

37

147*

 11q23

10

165*

 -5/7 (q)

31

102*

 trisomy 8

26

109*

 Complex

23

104*

 t (6;9)

5

176*

 t (9;22)

3

78

 -9(q)

7

88

FAB groups

 M0

48

145*

 M1

136

90*

 M2

157

37

 M3

34

172*

 M4

108

39

 M4E

5

185*

 M5

110

68*

 M6

9

42

Molecular mutations

 FLT3-ITD

132

128*

 FLT3-TKD

46

64

 NPM1

154

151*

 CEBPA

33

97

 NRAS

44

143*

 KRAS

4

171*

 EV1

28

163*

 RUNX1

11

143*

Total number of patients

607

 
  1. *significant enrichment (p-value <0.01) for p53 pathway-related genes