Basal-like breast cancer: molecular profiles, clinical features and survival outcomes

BMC Medical Genomics

Table 5 Cytobands associated with significant CNA acquisitions

Type	Cytobands	Training set	Validation set
		p-value	p-value
Gain	1q21.1	0.055	0.0012
	1q22	0.012	0.033
	1q23.1	0.038	0.024
	1q24.1	0.123	0.064
	1q32.3	0.099	0.14
	1q42.11	0.012	0.017
	1q42.12	0.08	0.015
	1q42.13	0.023	0.0059
	1q42.3	0.12	0.03
	1q43	0.0063	0.012
	1q44	0.021	0.049
	3q28	0.044	0.016
	8q13.2	0.044	0.054
	8q21.13	0.14	0.037
	8q22.1	0.092	0.06
	8q22.2	0.097	0.065
	8q23.2	0.12	0.0096
	8q24.11	0.075	0.049
	8q24.21	0.05	0.039
	8q24.22	0.012	0.086
	10p15.3	0.1	0.004
	10p12.32	0.12	0.013
	17q25.1	0.06	0.1
Loss	4q35.1	0.021	0.015
	5q12.2	0.15	0.04
	5q14.3	0.06	0.1
	8p21.2	0.046	0.027
	8p21.1	0.085	0.043
	Xp22.13	0.066	0.046
	Xp21.2	0.049	0.059
	Xq13.3	0.066	0.053
	Xq21.2	0.14	0.12
	Xq21.32	0.066	0.053

Chromosome aberrations in cytobands are classified into two major types: amplifications/gains and deletions/losses. The p-values were calculated using the binomial test with respect to the global distribution

ISSN: 1755-8794