Table 1 Functional analysis results of GRMD-induced gene alterations
From: GRMD cardiac and skeletal muscle metabolism gene profiles are distinct
GO Biological Process/Pathway | MHG at 6 m | LV at 6 m | ||||
|---|---|---|---|---|---|---|
No | NES | p val | No | NES | p val | |
Actin filament organization | 36 | 1.91 | 0.001 | - | ||
Regulation of extrinsic apoptotic pathway | 37 | 1.70 | 0.001 | - | ||
Regulation of cytoskeleton organization | 31 | 1.79 | 0.0021 | - | ||
ECM disassembly | 20 | 1.78 | 0.0064 | - | ||
Endothelial cell differentiation | 15 | 1.77 | 0.0078 | - | ||
Regulation of actin filament organization | 57 | 1.64 | 0.0081 | - | ||
Protein localization to organelle | 55 | 1.58 | 0.006 | - | ||
Inflammatory response | 100 | 1.55 | 0.002 | - | ||
Stem cell differentiation | 24 | 1.54 | 0.0305 | - | ||
Positive regulation of cell-substrate adhesion | 24 | 1.54 | 0.0369 | - | ||
Regulation of ion homeostasis | 32 | 1.52 | 0.0327 | - | ||
Immune system process | 369 | 1.50 | 0.001 | - | ||
Endocytosis | 111 | 1.50 | 0.006 | - | ||
Regeneration | 36 | 1.50 | 0.0369 | - | ||
Muscle structure development | 51 | 1.46 | 0.0433 | - | ||
Regulation of cell-cell adhesion | 74 | 1.45 | 0.025 | - | ||
Angiogenesis | 58 | 1.44 | 0.0351 | - | ||
Cell motility | 167 | 1.43 | 0.008 | - | ||
Regulation of cell proliferation | 233 | 1.39 | 0.012 | 19 | ns | |
Regulation of cell differentiation | 206 | 1.38 | 0.013 | 20 | ns | |
Cellular macromolecule localization | 149 | 1.35 | 0.028 | - | ||
Oxidation reduction | 98 | −2.82 | 0.001 | 16 | ns | |
Carboxylic acid catabolism | 29 | −2.58 | 0.001 | - | ||
Generation of precursor metabolites and energy | 45 | −2.45 | 0.001 | - | ||
Cellular respiration | 24 | −2.44 | 0.001 | - | ||
Mitochondrion organization | 73 | −2.35 | 0.001 | - | ||
Organonitrogen compound metabolism | 153 | −2.24 | 0.001 | 28 | ns | |
Coenzyme metabolism | 39 | −2.23 | 0.002 | - | ||
Small molecule metabolism | 176 | −2.20 | 0.001 | 30 | ns | |
Catabolic process | 142 | −2.18 | 0.001 | 19 | ns | |
Hexose metabolism | 22 | −2.12 | 0.0042 | - | ||
Glucose metabolism | 21 | −2.05 | 0.0058 | - | ||
Regulation of ketone metabolism | 26 | −2.05 | 0.002 | - | ||
Cofactor metabolism | 46 | −1.93 | 0.0038 | - | ||
Macroautophagy | 27 | −1.93 | 0.0039 | - | ||
Nitrogen compound transport | 31 | −1.93 | 0.0118 | - | ||
Protein ubiquitination | 63 | −1.88 | 0.0062 | - | ||
Organophosphate metabolism | 84 | −1.86 | 0.0117 | - | ||
Small molecule biosynthesis | 48 | −1.85 | 0.0096 | - | ||
NTP metabolism | 21 | −1.82 | 0.0081 | - | ||
Autophagy | 33 | −1.79 | 0.022 | - | ||
Cellular amino acid catabolism | 21 | −1.78 | 0.0135 | - | ||
Alpha amino acid catabolism | 17 | −1.74 | 0.0259 | - | ||
Macromolecule metabolism | 60 | −1.71 | 0.0279 | - | ||
Anion transmembrane transport | 21 | −1.63 | 0.041 | |||
Carbohydrate metabolism | 63 | −1.62 | 0.0299 | - | ||
Acyl-CoA metabolism | 18 | −1.62 | 0.0433 | - | ||
Regulation of transport | 120 | ns | 19 | −2.11 | 0.001 | |
MHG at 12 m | LV at 12 m | |||||
No | NES | p val | No | NES | p val | |
DNA metabolism | 18 | 1.80 | 0.0045 | - | ||
Lipid biosynthesis | 15 | 1.66 | 0.0216 | - | ||
Cell projection organization | 37 | 1.62 | 0.0249 | - | ||
Cellular response to stress | 38 | 1.62 | 0.0227 | - | ||
Cell proliferation | 19 | 1.53 | 0.0473 | - | ||
Regulation of cellular protein localization | 22 | 1.53 | 0.0378 | - | ||
Regulation of organelle organization | 33 | 1.50 | 0.041 | - | ||
Regulation of transport | - | 19 | −1.76 | 0.013 | ||