Fig. 2

Graphical abstract of CVE workflow. Variants of interest identified in high-throughput sequencing cancer studies are annotated using the Oncotator Variant Annotation tool. Using this annotation, we developed an interactive web application for variant prioritisation named Cancer Variant Explorer (CVE). Prioritisation is based on known germline and cancer variants, DNA repair genes and functional prediction scores. Exploration of the tumour-specific pathway context is facilitated using co-expression modules generated from publicly available transcriptome data. Finally druggability of prioritised variants are assessed using the Drug Gene Interaction Database (DGIdb)