Fig. 3

Weighted co-expression network analysis. a Gene dendrogram obtained by average linkage hierarchical clustering of TCGA melanoma RNA-seq data (n=472). Colour bar under the plot shows the module assignment determined by the Dynamic Tree Cut algorithm. b Eigengene phylogram of the 41 co-expression modules and module 0 (grey dot at 2 o’clock), which contains all genes not included in any of the co-expression modules. c Graphical summary of the module significance for the 5 gene significance measures as displayed in Cancer Variant Explorer. Modules are named according to the most significant GO term in the enrichment analysis with less than 100 genes per term (to exclude uninformative, high-level GO terms). Barplots show the average absolute gene significance measure per module, i.e. the module significance