From: CVE: an R package for interactive variant prioritisation in precision oncology
Variant | Patient id | dbNSFP score | COSMIC | Drug | Database |
---|---|---|---|---|---|
EPHA2:p.S790F | 26, 52 | 1.768360 | Â | tyrosine kinase inhibitor | T |
EPHA2:p.E607K | 48, 87 | 1.737764 | Â | tyrosine kinase inhibitor | T |
GART:p.S635F | 50, 56 | 0 | Â | folate antimetabolite | T |
KDR:p.S1100F | 16, 45, 75 | 2.679266 | Â | tyrosine kinase inhibitor | T & M |
KIT:p.K642E | 3, 27, 31, 70 | 2.454228 | yes | tyrosine kinase inhibitor | T & M |
KIT:p.V559A | 25, 38 | 2.650527 | yes | tyrosine kinase inhibitor | T & M |
LHCGR:p.E206K | 44, 45 | 0.77191 | yes | GnRH agonist | T |
MS4A1:p.G115E | 52, 79 | 0 | Â | anti-CD20 antibody | T & M |
MTOR:p.A1105T | 65, 66 | 0.8908875 | yes | mTOR inhibitor | T & M |
PDCD1:p.E211K | 34, 51 | 0 | Â | anti-PD1 antibody | M |
PIK3C2G:p.E1231K | 23, 48 | 0 | Â | PI3K inhibitor | M |
PRKCB:p.R361Q | 44, 50 | 0.959385 | Â | protein kinase C inhibitor | M |
ROS1:p.P1539S | 20, 26 | 0 | Â | tyrosine kinase inhibitor | M |