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Fig. 4 | BMC Medical Genomics

Fig. 4

From: N-of-1-pathways MixEnrich: advancing precision medicine via single-subject analysis in discovering dynamic changes of transcriptomes

Fig. 4

Joint effect of the pathway size and proportion of dysregulated mRNAs on the performance of MixEnrich method. Panel a shows an example contour plot of the AUC values under the combination of the four parameters (values are shown at the up-right corner in the contour plot) for MixEnrich. Every point in the contour plot is colored by the AUC value, with the color key shown in the upper left corner of the panel. Points with the same AUC values are connected by contour lines in the plot. We used area above the 95% curve (AAC95%; white area above the contour line of AUC = 0.95) as the overall joint performance measure when the two parameters change simultaneously. Panel b shows the distribution of every possible AAC95% for each method; each boxplot includes 234 data points; each point in a boxplot corresponds to a specific combination of the four other parameters: bg.Pct, bg.FC, p.upPct, and p.FC while allowing p.S and p.dPct to vary

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