N-of-1- pathways MixEnrich: advancing precision medicine via single-subject analysis in discovering dynamic changes of transcriptomes

BMC Medical Genomics

Table 3 Simulation parameters

Parameter	Description of the parameter	Values tested
bg.FC	Fold change of dysregulated background mRNAs	{1, 1.3, 1.5, 2}
bg.dPct	Percentage of dysregulated mRNAs as noise in the background	{0, 0.01, 0.05, 0.1, 0.2}
p.S	Number of mRNAs randomly chosen in the target pathway	{5, 10, [15, 490] by step 25, 500}
p.dPct	Percentage of dysregulated mRNAs in the target pathway	{(0, 1] by step 0.05}
p.FC	Fold change of mRNAs in the target pathway	{1.3, 1.5, 2}
p.upPct	Percentage of up-regulated mRNAs among dysregulated mRNAs in the target pathways	{0, 0.1, 0.2, 0.3, 0.4, 0.5}