Table 3 Gene-based association results (p-values) of common variants (MAF ≥ 5%; SNPs and Indels) of genes near the APOE region with CSF biomarker Aβ1-42 with and without adjusting for APOE genotypes
Gene | SNP + Indel | SNP | ||
|---|---|---|---|---|
p-value | p-value adjusted for APOE genotype | p-value | p-value adjusted for APOE genotype | |
BCL3 | 0.0013 | 0.0005 | 0.0019 | 0.0005 |
CBLC | 0.0006 | 0.0122 | 0.0005 | 0.0128 |
BCAM | 0.0014 | 0.0132 | 0.0016 | 0.0131 |
PVRL2 | <1.0E-05 | 0.6852 | <1.0E-05 | 0.6665 |
TOMM40 | <1.0E-05 | 1.0000 | <1.0E-05 | 1.0000 |
APOE | <1.0E-05 | 0.1380 | <1.0E-05 | 1.0000 |
APOC1 | <1.0E-05 | 1.0000 | <1.0E-05 | 1.0000 |
APOC1P1 | <1.0R-05 | 1.000 | <1.0E-05 | 1.0000 |
APOC4 | 0.1718 | 1.000 | 0.1437 | 1.0000 |
APOC2 | 0.0406 | 0.0621 | 0.0152 | 0.0570 |
CLPTM1 | 0.0198 | 0.0467 | 0.0331 | 0.0464 |
RELB | 0.0515 | 0.6551 | 0.2485 | 0.6095 |