Fig. 1

Overview of the proposed framework for identifying subtype-specific association patterns. For target gene estimation, our weighted lasso framework requires a covariate matrix and subtype information on samples. Note that four colors in Breast Cancer Subtype field correspond to subtypes, Luminal A, Luminal B, HER2 positive, and Triple Negative, respectively. With two inputs mixed from a kernel method, target genes in each of the subtypes are estimated based on DNA methylation features