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Table 3 Pathway over-representation analysis of 120 genes associated with interactions between miRNA and methylation

From: Identification of epigenetic interactions between miRNA and DNA methylation associated with gene expression as potential prognostic markers in bladder cancer

Reactome pathway name

p-value

FDR q-value

Oncogene induced senescence

0.0002

0.019

Deactivation of the beta-catenin transactivating complex

0.0002

0.019

Pre-NOTCH transcription and translation

0.0004

0.023

Oxidative stress induced senescence

0.001

0.025

NCAM1 interactions

0.001

0.025

PIP3 activates AKT signaling

0.002

0.025

PI-3 K cascade:FGFR1

0.002

0.025

PI-3 K cascade:FGFR2

0.002

0.025

PI-3 K cascade:FGFR3

0.002

0.025

PI-3 K cascade:FGFR4

0.002

0.025

PI3K events in ERBB4 signaling

0.002

0.025

PI3K events in ERBB2 signaling

0.002

0.025

Pre-NOTCH expression and processing

0.002

0.025

Cellular senescence

0.002

0.025

PI3K/AKT activation

0.002

0.025

GAB1 signalosome

0.002

0.025

Role of LAT2/NTAL/LAB on calcium mobilization

0.003

0.027

repression of WNT target genes

0.005

0.044

Downstream signaling events of B Cell Receptor (BCR)

0.005

0.047

AKT phosphorylates targets in the cytosol

0.006

0.048

Negative regulation of the PI3K/AKT network

0.006

0.048

Cyclin D associated events in G1

0.007

0.048

G1 phase

0.007

0.048