Fig. 1

Cryptic splicing discovered by the CryptEx pipeline. a Schematic of the three classes of cryptic exon. Black boxes represent annotated exons and red boxes represent a cryptic exon. Grey lines represent the spliced intron. b Tally of the three classes of cryptic exon discovered by the CryptEx pipeline across the nine datasets. “Unfiltered output” refers to the number of differentially used cryptic splicing events at a false discovery rate (FDR) < 5% before undergoing cryptic exon classification. Counts from Ling et al’s data are taken from the paper itself. c Venn diagrams showing the overlap between the six TDP-43 depletion datasets