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Fig. 2 | BMC Medical Genomics

Fig. 2

From: Quantitative analysis of cryptic splicing associated with TDP-43 depletion

Fig. 2

Evidence of TDP-43 binding cryptic exons. a Results of MEME motif search. Only the motif with the greatest enrichment compared to background sequence is presented. b Dinucleotide enrichment in the flanked cryptic exons compared to adjacent introns. c Schematic of iCLIP peak enrichment test. For illustration a cassette-like cryptic exon (green box) is shown between two annotated exons (black boxes) separated by intronic sequence (black lines). The proportion of the group of cryptic exons flanked either side by 100 nucleotides (orange) that overlap at least one iCLIP peak is compared to the proportion of overlaps in a group of length matched sequences from either the surrounding intron (yellow) or an adjacent intron (blue) each randomly sampled 100 times per gene. d iCLIP peak overlap enrichment for the 95 human cryptic exons found in either K562 cell TDP-43 depletion dataset and the 52 cryptic exons found in either mouse TDP-43 depletion dataset. Error bars denote 95% confidence intervals of the binomial distribution. P < 0.05, P < 0.001, P < 10−16. All P-values adjusted for multiple testing by Bonferroni method

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