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Table 3 Predicted PPI- hubs

From: In silico identification of potential key regulatory factors in smoking-induced lung cancer

Symbol

Description

Literature evidence

MEPCE

7SK snRNA methylphosphate capping enzyme or Bicoid-interacting protein 3 homolog (Bin3 homolog)

[3]

CDK1

Cyclin-dependent kinase 1

[65]

PRKCA

Protein kinase C alpha type or PKC-A

[66]

COPS5

COP9 signalosome complex subunit 5

[67, 68]

GSK3B

Glycogen synthase kinase-3 beta

[69]

BRCA1

Breast cancer type 1 susceptibility protein

[70, 71]

EP300

Histone acetyltransferase p300 or p300 HAT

[72, 73]

PIN1

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

[74, 76]